曲美他嗪对X综合征患者预后的影响

Influence of trimetazidine on prognosis of patients with X syndrome

目的:探讨曲美他嗪(TMZ)与传统常规药物相结合对心脏X综合征预后的影响。方法:80例心脏X综合征患者被随机均分为常规治疗组和TMZ组(传统常规药物治疗的基础上加用TMZ 20mg,3次/d),治疗12周,分别在治疗前后对两组患者进行平板运动试验及心功能检查,并进行统计学比较。结果:治疗后与常规治疗组比较,TMZ组总运动时间[(7.90±1.45)min比(9.35±1.70)min],ST段下降l mm的时间[(5.30±1.43)min比(6.78±2.00)min]明显延长,ST段压低幅度明显减小[(0.89±0.30)mm比(0.61±0.20)mm],P均<0.05;心脏功能方面,搏出量[(67.99±11.77)ml比(74.05±7.58)ml]、左室射血分数[(50.13±11.05)%比(56.02±9.52)%]均明显增加(P均<0.01)。结论:TMZ能明显改善心脏X综合征患者的预后。

Objective：To explore the influence of trimetazidine （TMZ）combined traditional routine drugs on progno-sis of patients with cardiac syndrome X.Methods：A total of 80 patients with cardiac syndrome X were randomly and equally divided into routine treatment group and TMZ group （received TMZ 20mg,three times/d based on routine medication）.Both groups were treated for 12 weeks.Patients of two groups received treadmill exercise test and car-diac function examination before and after treatment,and the results were statistically compared.Results：Com-pared with routine treatment group after treatment,there were significant rise in total exercise time [（7.90±1.45） min vs.（9.35±1.70）min]and the time ST segment depressed 1mm [（5.30±1.43）min vs.（6.78±2.00）min], and significant reduction in ST segment depression extent [（0.89±0.30）mm vs.（0.61±0.20）mm],P 〈0.05 all;for cardiac function,there were significant rise in stroke volume [（67.99±11.77）ml vs.（74.05±7.58）ml]and left ventricular ejection fraction [（50.13±11.05）% vs.（56.02±9.52）%]in TMZ group,P 〈0.01 all.Conclusion：TMZ can significantly improve prognosis of patients with cardiac syndrome X.