替米沙坦联合硝苯地平控释片对肥胖高血压患者的疗效

Therapeutic effect of telmisartan combined nifedipine in patients with obese and hypertension

目的：探讨替米沙坦联合硝苯地平对肥胖高血压患者的疗效及对患者血脂的影响。方法：选择2011年1月～2012年12月在我院住院治疗的180例肥胖性高血压患者作为研究对象，按照随机数字表法均分为硝苯地平组和硝苯地平联合替米沙坦组（联合用药组），观察两组的疗效，血脂等的变化。结果：在6周治疗后，与硝苯地平组比较，联合用药组总有效率明显升高（75.56％比93.33％，P ＜0.05）；总胆固醇[TC，（5.20±0.59）mmol／L 比（4.75±0.73）mmol／L]和甘油三酯[TG，（1.87±0.49）mmol／L 比（1.67±0.48）mmol／L]以及血压水平[（138±9）／（90±6）mmHg 比（125±9）／（81±5）mmHg]均明显降低（P ＜0.05）。结论：替米沙坦联合硝苯地平控释片对肥胖高血压患者的疗效显著，还有降低血脂的作用。

Objective：To explore the therapeutic effect of telmisartan combined nifedipine in patients with obese and hypertension and its influence on patients′blood lipid level.Methods：A total of 180 patients with obese and hyper-tension,who hospitalized in our hospital from Jan 2011 to Dec 2012,were enrolled as subjects.According to random number table method,they were equally divided into nifedipine group and nifedipine combined telmisartan group （combined medication group）.Therapeutic effects,changes of levels of blood lipids etc.were observed in two groups.Results：After six-week treatment,compared with nifedipine group,total effective rate of combined medi-cation group significantly rose （75.56%vs.93.33%,P 〈0.05）;the levels of total cholesterol [TC,（5.20±0.59） mmol/L vs.（4.75±0.73）mmol/L],triglyceride [TG,（1.87±0.49）mmol/L vs.（1.67±0.48）mmol/L]and blood pressure [（138±9）/ （90±6）mmHg vs.（125±9）/ （81 ±5）mmHg]significantly reduced in combined medication group,P 〈0.05 all.Conclusion：Telmisartan combined nifedipine possess significant therapeutic effect on obese and hypertension,it also can lower blood lipid levels.