丹红注射液对STEMI患者PCI术后IL-17等表达的影响

Influence of Danhong injection on IL-17 expression after PCI in STEMI patients

目的:观察丹红注射液对ST抬高型心肌梗死(STEMI)患者经皮冠状动脉介入术(PCI)术后白细胞介素17(IL-17)等表达的影响,并探讨其对PCI术后缺血-再灌注损伤(MIRI)的作用。方法:选择心内科行PCI治疗的STEMI患者300例,随机分为常规治疗组和丹红注射液治疗组,每组150例。采用酶联免疫法(ELISA)测定IL-17和IL-6水平。结果:两组术前IL-17和IL-6表达水平无显著性差异(P>0.05),术后12h两组IL-17和IL-6表达水平均显著升高(P<0.05),以后逐渐下降,术后72h常规治疗组IL-17和IL-6表达水平仍然高于术前(P<0.05),但丹红组的已与术前无显著性差异(P>0.05)。丹红组临床治疗总有效率显著高于常规治疗组(92.7%比81.3%,P<0.05)。72h时与常规治疗组比较,丹红组IL-17[(31.4±6.1)ng/ml比(23.2±4.3)ng/ml]和IL-6[(60.3±11.6)ng/ml比(42.7±8.4)ng/ml]水平显著降低,左室射血分数显著提高[(43.6±4.5)%比(53.7±5.6)%],心肌梗死面积显著减小[(22.7±4.3)%比(17.2±3.7)%],P均<0.05。结论:丹红注射液降低IL-17和IL-6因子表达,可能是改善PCI术后MIRI的机制,从而缩小心肌梗死面积,改善心功能,具有临床推广应用价值。

Objective：To observe the influence of Danhong injection on interleukin-17 （IL-17）expression after percu-taneous coronary intervention （PCI）in patients with ST segment elevation myocardial infarction （STEMI）,and ex-plore its protective effect on myocardial ischemia-reperfusion injury （MIRI）after PCI.Methods：A total of 300STEMI patients undergoing PCI in department of cardiology were selected.They were randomly divided into routine treatment group （n=150）and Danhong injection group （n=150）.Enzyme linked immunosorbent assay （ELISA） was used to measure levels of IL-17 and IL-6. Results：There were no significant difference in expression levels of IL-17 and IL-6 between two groups before PCI （P 〉0.05）.On 12h after PCI,IL-17 levels of two groups signifi-cantly rose （P 〈0.05）,then gradually declined,IL-17 and IL-6 levels in routine treatment group were still signifi-cantly higher than those of before PCI （P 〈0.05）,but those of Danhong group were not significantly different from before PCI （P 〉0.05）.Total effective rate of Danhong group was significantly higher than that of routine treat-ment group （92.7% vs.81.3%,P 〈0.05）.Compared with routine treatment group on 72h after PCI,there were significant reductions in levels of IL-17 [（31.4±6.1）ng/ml vs.（23.2±4.3）ng/ml]and IL-6 [（60.3±11.6）ng/ml vs.（42.7±8.4）ng/ml],significant rise in left ventricular ejection fraction [（43.6±4.5）% vs.（53.7±5.6）%] and significant reduction in myocardial infarction area [（22.7±4.3）% vs.（17.2±3.7）%]in Danhong injection group,P 〈0.05 all.Conclusion：Danhong injection decreases expressions of IL-17 and IL-6,it may be mechanism improving MIRI after PCI,thereby diminishes myocardial infarction area,and improves heart function,which is worthy extending.