联合检测胃蛋白酶原亚型、CEA、CA724在胃癌诊断中的临床意义

Combined detection of pepsinogenⅠ and Ⅱ , CEA, and CA724 in diagnosis of gastric cancer

目的探讨血清胃蛋白酶原Ⅰ、Ⅱ、CA724、CEA及Ⅰ／Ⅱ含量变化与胃癌发生的关系，探讨其在胃癌早期诊断中的临床价值。方法在我院进行检查的250例胃病患者作为研究对象。其中良性病变患者135例作为对照组，胃癌患者115例作为观察组，两组均进行PG、CEA、CA724的检测。结果观察组CEA、CA724和PGⅡ显著高于对照组，PGⅠ显著低于对照组（P〈0．01）。（CEA＋CA724＋PG）阳性率显著大于各双项指标和各单项指标阳性率（P〈0．01）。结论CEA和CA724的敏感性较高，可以在癌症早期就出现明显的指标升高；PG的特异性较高，其对于定性胃癌具有重要意义，同时还可降低假阳性率。三项指标联合检测，兼具高特异性和敏感性的特点，有助于更为准确、高效的诊断胃癌。

Objective To explore the correlation between gastric cancer and the serum levels of pepsinogen Ⅰand Ⅱ, CA724, and CEA and the variation of pepsinogen Ⅰ and Ⅱ and to explore these indicators＇ clinical value in the early diagnosis of gastric cancer. Methods 250 patients with gastric disease checked in our hospital were selected as study objects. Among which, 135 patients with benign lesions were set as a control group, and 115 patients with gastric cancer an observation group. PG, CEA, and CA724 were detected in both groups. Results The serum levels of CEA, CA724, and PG Ⅱ were significantly higher and the serum level of PG Ⅰ was significantly lower in the observation group than in the control group （P〈0.01）. The positive rate of the combination of CEA, CA724, and PG was significantly higher than those of any two these indicators＇ combination and any one of these indicators（P〈0.01）.Conclusions CEA and CA724 has a high sensitivity, so would increase during early cancer period. PG has a high specificity, so has important implications for qualitative gastric cancer and can reduce the false positive rate. Combination of three indicators has high specificity and sensitivity and is helpful for diagnosing gastric cancer accurately and efficiently.