子宫内膜异位症保守性术后应用GnRH-a治疗对复发的影响

Treatment effect of GnRH-a for endometriosis after conservative surgery on its recurrence

目的探讨子宫内膜异位症保守性术后应用GnRH—a治疗对复发的影响。方法选取笔者收治的腹腔镜保守性术后108例子宫内膜异位症不孕症患者，将其随机分为观察组以及对照组；对照组单纯进行手术治疗，观察组在术后予以GnRH—a治疗，比较两组治疗效果、复发率、疼痛缓解率以及不孕妊娠率。结果观察组完全缓解率与对照组相比明显升高，复发率明显降低，P〈0．05。观察组术后疼痛缓解率（85．19％）明显高于对照组（62．96％），P〈0．05。其中41例不孕症患者，观察组术后2年妊娠率（64．81％）明显高于单纯手术组（31．48％），P〈0．05。结论腹腔镜保守手术术后联合药物GnRH—a对中重度子宫内膜异位症进行治疗可明显降低患者术后复发率，提高术后妊娠率，值得临床上推广应用。

Objective To explore treatment effect of GnRH-a for endometriosis after conservative surgery on its recurrence. Methods 108 infertility patients with endometriosis treated with laparoscopic conservative operation were selected and then were randomly divided into an observation group and a control group. The control group were surgically treated, while the observation group were treated with GnRH-a after the operation. The treatment effect, recurrence rate, pain relief rate, and pregnant rate were compared between the two groups. Results The complete remission rate was markedly higher and the recurrence rate was obviously lower in the observation group than in the control group （P〈0.05）. The postoperative pain relief rate was significantly higher in the observation group（85.19%） than in the control group （62.96%）, （P〈0.05）. Among the 41 infertility patients, the pregnant rate was obviously higher in the observation group （64.81%） than in the control group （31.48%） 2 years after the operation（P〈0.05. Conclusions GnRH-a for severe endometriosis after laparoscopic conservative surgery can obviously reduce the patients＇ recurrence rate and improve the pregnant rate after operation and is worth being clinically generalized.