咪达唑仑在俯卧位机械通气治疗NRDS中的临床应用

Clinical application of midazolam in treating NRDS with mechanical ventilation in prone position

目的探讨咪达唑仑在俯卧位机械通气治疗NRDS中的应用效果。方法将94例NRDS患儿分为观察组和对照组，两组均给予俯卧位机械通气治疗，观察组给予咪达唑仑辅助治疗，对照组给予苯巴比妥辅助治疗，观察两组治疗效果。结果两组PaO2、PaCO2、MAP及FiO2均有明显改善，但观察组改善更加明显（P〈0．05）；观察组机械通气后各时点疼痛评分均明显低于对照组（P〈0．05）；观察组呼吸机使用时间及平均住院时间均明显短于对照组（P〈0．05）。结论咪达唑仑可提高俯卧位机械通气治疗NRDS的治疗效果，具有更好的应用价值。

Objective To investigate the application effect of midazolam in treating NRDS with mechanical ventilation in prone position. Methods 94 NRDS cases were divided into an observation group and a control group. Both groups were treated with mechanical ventilation in prone position, while the observation group was treated with midazolam and the control group was additionally treated with phenobarbital. The efficacies were observed in both groups. Results The PaO2, PaCO2, MAP, and FiO2 were significantly improved in both groups, but more obviously in the observation group than in the control group（P〈0.05）. After mechanical ventilation, the pain evaluation scores were significantly lower at all the time points in the observation group than in the control group （P〈0.05）. The average time using respirators and average hospitalization time were significantly shorter in the observation group than in the control group （P〈0.05）. Conclusions Midazolam can enhance the efficacy of mechanical ventilation in prone position in the treatment of NRDS, which shows its good application value.