脑供血动脉栓塞动物模型制作方法讨论

Manufacture Method of Cerebral Embolism Animal Model

目的通过研究脑供血动脉栓塞动物模型的制作方法,为应用介入技术溶栓治疗脑栓塞的相关技术培训提供一种有效的疾病模型。方法 30头家猪平均分三组,分别采用线栓法、介入栓塞法及手术切开栓塞法制作猪脑供血动脉栓塞动物模型,通过比较三种方法的优缺点,确定一种操作简单、适宜介入下溶栓治疗脑栓塞培训的模型制作方法用于相关培训。结果介入栓塞法制作模型成功率为90%(9/10),线栓法制作模型成功率为50%(5/10),手术切开栓塞法制作成功率为0%(0/10)。结论介入栓塞法制作猪脑供血动脉栓塞模型成功率高,可重复性强,可以为培训介入下脑栓塞溶栓治疗提供一种良好的疾病模型。

Objective Through the method of making animal model of cerebral embolism, technical training related to interventional thrombolytic therapy cerebral embolism provide a model for effective disease. Methods 60 experimental pigs divided into three groups, respectively, by using the suture method and operation, interventional embolization in artery of cerebral embolism animal model with brain embolism, by comparing the advantages and disadvantages of the three methods, to determine a simple operation, suitable for interventional thrombolytic therapy cerebral embolism training model making method for training. Results Interventional method making model success rate was 90%（18/20）, intraluminal filament model success rate was 50%（10/20）, operation and embolization produced the success rate was 0%（0/20）. Conclusion Fabrication of swallow up arteries stroke model with high success rate of interventional method, strong repeatability, can provide a good model for training intervention therapy of cerebral embolism thrombolysis