尿微量白蛋白检测在老年高血压患者早期肾损害中的临床价值

Clinic Value of Urinary Microalbumin Test on Early Kidney Lesion in Aged Patients With Essential Hypertension

目的探讨尿微量白蛋白(m ALB)检测在老年原发性高血压(EH)患者早期肾损害中的临床价值。方法选择于我院就诊的老年EH患者及健康老年人各110例作为观察组和对照组,测定并比价两组患者m ALB、血尿素氮(BUN)与肌酐(C r)。结果观察组尿m ALB阳性率为37.27%,显著高于对照组的4.55%(P<0.01),观察组尿m ALB值为(43.07±11.33)mg/L,显著高于对照组(P<0.01),而血BUN和血Cr比较差异无统计学意义(P>0.05)。观察组Ⅰ-Ⅲ级EH尿m ALB逐渐升高(P<0.01),Ⅱ级、Ⅲ级EH的m ALB值显著高于对照组(P<0.01)。结论尿m ALB是诊断早期肾功能损害较为敏感的指标,老年EH患者定期检测尿微量白蛋白对发现早期肾损害有非常重要的临床价值。

Objective To investigate the clinic value of urinary microalbumin（mALB）test on early kidney lesion in aged patients with essential hypertension（EH）. Methods We selected elderly EH and healthy patients from our hospital（110 cases each group）,mALB,blood urea nitrogen（BUN）and creatinine（Cr） were compared. Results Positive rate of mALB in EH group was 37.27%,significantly higher than healthy control （4.55%）（P〈0.01）,mALB level of EH group was （43.07＆#177;11.33） mg/L,significantly higher than control group （P〈0.01）. While there was no significant differences in BUN and Cr compared with control（P〉0.05）. mALB level was gradual y increased in I-III stage of EH group （P〈0.01）,mALB level in patients with II and III stage EH was significantly higher than control （P〈0.01）. Conclusion Urinary mALB is a sensitive indicator for early kidney lesion,elderly EH patients with regularly urinary mALB test for detection of early kidney lesion have very important clinical value.