血浆置换治疗肝功能衰竭的临床疗效与生存质量分析

Clinical effi cacy and quality of life analysis of plasma exchange in the treatment of liver failure

目的探讨血浆置换治疗肝功能衰竭患者的临床疗效、不良反应及生存质量。方法收集103例肝功能衰竭患者进行血浆置换治疗。观察患者治疗前后肝功能指标及生存质量的变化以及治疗后不良反应的发生情况。应用SPSS统计软件进行数据分析。结果 103例患者血浆置换治疗后,TBil、ALT、AST、PTA、CHE与治疗前比较均有明显提升(P<0.05);治疗后不良反应的发生以过敏反应为主;患者治疗后生存质量各维度与治疗前相比,均有显著改善,差异有统计学意义(P<0.05)。结论血浆置换治疗肝功能衰竭具有较好的临床效果,同时能有效提高患者的生存质量,但应警惕不良反应的发生。

Objective To investigate the effi cacy, adverse reactions and quality of life of plasma exchange in the treatment of liver failure. Methods Total of 103 patients with liver failure, and all subjects were treated with plasma exchange for determination of the changes in the liver function indices and adverse reactions, as well as quality of life. SPSS was used to analyze the data. Results Following plasma exchange, there had a signifiant difference in TBil, ALT, AST, PTA and CHE levels（P〈 0.05）. The major adverse reactions comprised of plasma allergic reactions. The quality of life in all dimensions had a signifi ant improvement than that of pre-treatment（P〈 0.05）. Conclusions Plasma exchange achieves siginifi cant effi cacy and quality of life for the treatment of liver failure, but should warrant prevention of the complications.