AFP和高尔基体糖蛋白-73联合检测诊断原发性肝癌临床评价

Combined diagnosis value of Golgi protein 73 and alpha-fetoprotein in primary hepatic cancer

目的探讨甲胎蛋白(AFP)和高尔基体糖蛋白-73(GP73)在PHC诊断中的指导意义。方法采用电化学发光法分别对64例肝癌组和72例对照组进行血清AFP及GP73的含量检测,分析AFP、GP73及AFP和GP73联合检测时在PHC诊断时的敏感性和特异性。结果 64例PHC癌患者中,57例(89.01%)为肝细胞癌。AFP和GP73在肝癌组患者血清中的含量分别为(318.27±169.32)ng/ml和(262.74±168.98)ng/ml,明显高于对照组血清中的(14.16±8.45)ng/ml和(37.04±20.56)ng/ml,P均<0.01。AFP和GP73联合检测敏感性及特异性可达88.39%和86.36%,与单项检测相比,可明显提高诊断的准确性。结论血清中AFP及GP73是PHC发生、发展的重要检测指标,两者联合检测对肝癌患者诊断及预后具有重要。

Objective To investigate the effect and diagnostic signifi cance of alpha-fetoprotein（AFP） and Golgi protein 73（GP73） in the serum of primary hepatic cancer（PHC） patients. Methods We retrospectively analyze 64 cases of liver cancer and 72 healthy people respectively by electrochemiluminescence determination of serum AFP and GP73. The sensitivity and specifi city of serum AFP, GP73, and AFP ＋ GP73 in the diagnosis of PHC were analyzed. Results The 89.01%（57/64） of PHC patients were HCC patients and AFP ＋ GP73. The serum levels of AFP and GP73 in PHC patients [（318.27 ± 169.32） ng/ml,（262.74 ± 168.98） ng/ml] were signifi cantly higher than in healthy people [（14.16 ± 8.45） ng/ml,（37.04 ± 20.56） ng/ml]（P 0.01）. The sensitivity and specifi city value of AFP combined with GP73 were 88.39% and 86.36%, respectively. Compared with single detection, AFP and GP73 combined detection had an higher diagnosis accuracy in PHC. Conclusions Serum levels of AFP and GP73 are important factors of PHC occurrence and development indicators. The AFP and GP73 combined detection has important significance for PHC diagnosis and prognosis estimation.