重视肾脏病合并心脑血管疾病的防治

Attention to prevention and treatment of cardiovascular and cerebrovascular co-morbidities in patients with chronic kidney disease

慢性肾脏病(CKD)合并心脑血管疾病的发生率日益增多,心脑血管合并症是CKD进展和预后不良的重要危险因素,同时,肾小球滤过率的降低和蛋白尿也是心脑血管疾病发生和加重的独立危险因素,但在临床上CKD合并心脑血管疾病存在着明显的诊治不足的情况,而临床医师对CKD与心脑血管并发症之间复杂关系的认识也不尽充分。目前,临床医师不仅应该从临床现象和病理机制上厘清CKD与心脑血管疾病之间的相互关系,也需要对CKD合并心脑血管疾病的早期诊断和尚未认识的病理生理机制进行深入研究,我们相信今后的研究将会给CKD合并心脑血管疾病患者找到新的干预措施。

The incidence rate of cardiovascular and cerebrovascular diseases （CCDs） is now increasingly high in patients with chronic kidney disease （CKD）. CCDs are significant predictors of progression and poor outcomes of CKD. Meanwhile, reduced glomerular filtration rate and albuminuria are also independent risk factors of development and aggravation of CCDs. However, CCDs are obviously underdiagnosed and undertreated in patients with CKD. Renal impairment often influenced the efficacy of CCDs treatment, and the complex relationship between CKD and CCDs is recognized insufficiently by the clinicians. Now, we should make clear the interplay between CKD and CCDs from clinical phenomenon and pathological mechanisms. Further researches are needed to investigate early detection and unknown pathophysiological mechanisms of CCDs in patients with CKD. It can be believed that new therapeutic interventions will be found for CDDs in patients with CKD by the future research.