5-氨基酮戊酸光动力疗法治疗中、重度痤疮的疗效观察

The Study of Clinical Efficacy on 5-Aminolevulinic acid-photodynamic Thrapy in Treatment of Moderate and Severe Acne

目的:观察5-氨基酮戊酸光动力治疗中、重度痤疮的疗效及安全性。方法:共59例患者,随机分成治疗组和对照组。治疗组30例,给予5-氨基酮戊酸光动力治疗,一周治疗一次,共4次,治疗结束后继续随访3个月;对照组29例,给予异维A酸胶丸5mg/(kg.d)口服,共8周。结果:治疗组有效率为90.0%,对照组有效率为82.7,治疗组复发率为10%,对照组复发率为24.14%,两组疗效比较差异具有统计学意义,治疗组疗效优于对照组(P<0.05)。结论:5-氨基酮戊酸光动力治疗中、重度痤疮疗效安全,有效,复发率相对较低。

Objective： To observe the efficacy and safety of 5-Aminolevulinic acid-photodynamic （ALA-PDT） on patients with moderate and severe acne. Methods： Fifty-nine patients were randomly divided into treatment group and control group. Thirty patients with moderate to severe aene treated by with 5% ALA-PDT. Each patient was treated for four sessions. The patients were followed up for 3-months after treatment. Twenty-nine patients as control group were treated with by Isotretinion capsule, for 8 weeks, then observed effect. Results： The total effective rate of two groups was 90.0% and 82.7%. There were obvious statisties differences of efficacy between ALA-PDT and Isotretinion capsule only （P〈O. 05） . Conclutions： ALA-PDT which is effective and safe in treatment of moderate and severe acne surpassed the Isotretinion capsule.