白细胞介素-6和肿瘤坏死因子-α与大肠癌预后的关系

Relationship between IL-6 and TNF-α and outcome among colorectal cancer

目的观察大肠癌患者血清白细胞介素-6(IL-6)和肿瘤坏死因子α(TNF-α)水平变化,并探讨其临床意义。方法采用酶联免疫吸附法(ELISA)检测120例大肠癌患者血清中IL-6和TNF-α含量。确诊病例在术前清晨,术后1个月,术后1年分别采血,检测血清中IL-6和TNF-α含量。结果大肠癌患者血清中IL-6和TNF-α的含量明显高于健康者,且两组比较差异有统计学意义(均P<0.05),大肠癌患者血清中IL-6和TNF-α的水平随着肿瘤浸润深度的增加及临床分期的增高,患者血清中IL-6和TNF-α含量也随之增加。术后1个月病例复查均较术前明显降低,术后1年不同分期IL-6和TNF-α水平差异仍有统计学意义,其中复发9例,其IL-6和TNF-α水平较同组其他病例显著升高。结论 IL-6和TNF-α的检测对大肠癌的早期诊断和预后具有重要意义。提示可以以此来对大肠癌做出尽早的筛选,并且对手术效果有一定的判断作用。

[ Objective ] To detect the serum IL-6 and TNF-α level in patient with colorectal cancer and investi- gate its clinical significance. [Methods ] 120 patients were selected, and the serum of patients with colorectal cancer were obtained at specially designed time： the day before operation, postoperative first month, the first year. Serum IL-6 and TNF-α in study object were measured by enzyme-linked inmmnn sorbent assay （ELISA）. [Results] serum I1-6 and TNF-cdevel with colorectal cancer before surgery were significantly higher than healthy group. Serum IL-6 and TNF-α level were significantly correlated with depth of tumor invasion and TNM stage. Serum IL-6 and TNF-α level of postoperative first month were significantly lower than the day before operation. [ Conclusion ] The detection of serum 1L-6 and TNF-α level with colorecta cancer is meaningful for the early detection and prog- nosis of colorectal cancer and it has a potential role for colorectal cancer early screening and effect of surgery.