亚洲人群p53Arg72Pro基因多态性与胃癌易感性的Meta分析

p53Arg72Pro Polymorphism and Susceptibility to Gastric Cancer in Asian Population: a Meta-analysis

目的探讨p53基因多态性与亚洲人群胃癌易感性的关系。方法检索PubMed、EMbase、TheCochraneLi—brary和CBM、中国学术文献总库、维普、万方数据库，收集有关p53基因多态性与亚洲人群胃癌易感性有关的文献，最后检索日期为2014年5月，并追溯纳入研究的参考文献。由两位研究者按照纳入与排除标准独立筛选文献、提取资料和评价质量后，采用Statal3．0统计软件进行统计分析。以病例组及对照组p53基因型分布的比值比（OR值）为效应指标，计算合并OR值及95％可信区间，用漏斗图和Egger图评估。结果在亚洲人群中，病例组和对照组相比，携带杂合基因型（Arg／Pro）和突变纯合基因型（Pro／Pro）的个体发生胃癌的风险和野生纯合型（Arg／Arg）相比差异有统计学意义（OR=1．159，95％CI：1．025～1．33l，P=0．019）（P〈0．05）。结论与野生纯合型相比，携带杂合基因型和突变纯合基因型增加了患胃癌的风险．

Objective To examine the association between P53Arg72Pro polymorphisms and gastric cancer by systematically reviewing the risk of the original studies. Methods The literature search in CNKI, Pubmed,CBM, VIP ,WanFang Data Sci- ence Direct, Springer Link was carried out to find relevant papers. Disqualified studies were excluded. Odds ratio of p53Arg72Pro genotype distributions in the group of patients with stomach cancer and the group of healthy control was calcu- lated. The Meta-analysis was applied with statal 3.0 software for heterogeneity test and pooled RR calculation. Results The pooled OR values of Arg/Pro and Pro/Pro compared to Arg/Arg were （OR = 1. 159,95% CI：1. 025 - 1. 331, P = 0. 019 ） and 1. 061 （95 % C1：0. 985 - 1. 142 ）. Conclusion It is demonstrated that p53Arg72Pro genotype Arg/Pro and Pro/Pro are the important risk factors forsuseeptibility to human gastric cancer.