摘要
目的探讨丹参酮ⅡA（TanⅡA）对柔红霉素（DNR）所致大鼠心脏毒性的预防作用，为临床肿瘤治疗提供心脏防护策略。方法将50只4周龄心电图正常的雄性SD大鼠随机分为空白对照组、DNR组、TanⅡAI组、TanⅡAⅡ组、TanⅡAⅢ组，观察不同剂量（4、8、16mg／（kg·d））TanⅡA对大鼠心电活动、心功能的影响。结果TanⅡAⅠ、Ⅱ、Ⅲ组均未出现心律失常，左室射血分数、左室短轴缩短率明显高于与DNR组（P〈0．05），且呈剂量效应关系。结论8—16mg／kg TanⅡA能预防和减轻DNR对大鼠心肌细胞的损伤，具有心肌保护作用。
Objective To observe the preventive and protective effect of tanshinone Ⅱ A （ Tan Ⅱ A） on myocardial cell injury caused by soft erythromycin（DNR）. Methods The thirty-five four-week- old healthy male SD rats were randomly divided into five groups： control group, DNR group, Tan Ⅱ A Ⅰ group, Tan Ⅱ A Ⅱ group, Tan ⅡA Ⅲ group. The effects of different doses of Tan Ⅱ A on electrical activity and heart function in rats were observed. Results Compared with the DNR group, in Tan Ⅱ A Ⅰ , Ⅱ , Ⅲ group, the electrical activity and heart function detection value reduced（P 〈 0. 05） , and showed a dose-response relationship. Conclusions Einght mg/kg to 16 mg/kg Tan Ⅱ A can prevent and mitigate the DNR-induced myocardial cell injury in rats, with myocardial protection.
出处
《中国实用医刊》
2015年第5期26-28,共3页
Chinese Journal of Practical Medicine
关键词
丹参酮ⅡA
柔红霉素
心肌损伤
心电活动
心功能
Tanshinone Ⅱ A
Daunorubicin
Myocardial injury
Electrical activity
Heart function
