期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

STIM1在心血管疾病中的研究进展 被引量：4

Research Progress on STIM1 in Cardiovascular-related Diseases
下载PDF
导出
摘要 钙离子在细胞生存进程中起着至关重要的作用,例如细胞内信号传导,蛋白质折叠,酶的活化和程序性细胞死亡的启动。基质交感分子1(STIM1)是细胞内质网膜上的跨膜蛋白,其作为细胞内质网的钙离子传感器,可与胞膜下的Orai1蛋白结合,参与细胞内外钙浓度的调节。钙离子失调已被证实与多种心血管疾病有关,本文通过对STIM1在与心血管相关疾病中的作用进行回顾。 Calcium plays a vital role in cell survival process, such as intraeellular signaling, protein folding, enzyme activation and start programmed cell death. Stromal interaction molecule 1 （ STIM1 ） transmembrane protein within the cells of the endoplasmic reticulum, as endoplasmic retieulum calcium ion sensor can be combined with membrane proteins under Oral 1 involved in the regulation of intracellular calcium concentration.Calcium imbalance has been linked to avariety of cardiovascular diseases, this paperwere reviewed by STIM1 in cardiovascular-related diseases.
作者 梁霄 石蓓
机构地区 遵义医学院
出处 《中国医学创新》 CAS 2015年第5期154-156,共3页 Medical Innovation of China
关键词 钙离子 基质交感分子1 库操控的钙流入通道 Ca2＋ STIM1 SOCE
分类号 R54 [医药卫生—心血管疾病]
  • 相关文献

参考文献25

  • 1Putney J W Jr.A model for receptor-regulated calcium entry[J].Cell Calcium,1986,7(1):1-12.
  • 2高尚邦,李臣鸿.钙释放激活钙通道研究进展[J].现代生物医学进展,2009,9(2):350-354. 被引量：4
  • 3Roos J,Di Gregorio P J,Yeromin A V,et al.STIM1,an essential and conserved component of store-operated Ca2+channel function[J].J Cell Biol,2005,169(3):435-445.
  • 4Wu M M,Buchanan J,Luik R M,et al.Ca2+store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane[J].J Cell Biol,2006,174(6):803-813.
  • 5Hogan P G,Lewis R S,Rao A.Molecular basis of calcium signaling in lymphocytes:STIM and ORAI[J].Annu Rev Immunol,2010,28(14):491-533.
  • 6Stathopulos P B,Zheng L,Li G Y,et al.Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry[J].Cell,2008,135(1):110-122.
  • 7Liou J,Fivaz M,Inoue T,et al.Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+store depletion[J].Proc Natl Acad Sci USA,2007,104(22):9301-9306.
  • 8Zhang S L,Yu Y,Roos J,et al.STIM1 is a Ca2+sensor that activates CRAC channels and migrates from the Ca2+store to the plasma membrane[J].Nature,2005,437(7060):902-905.
  • 9Hogan P G,Lewis R S,Rao A.Molecular basis of calcium signaling in lymphocytes:STIM and ORAI[J].Annu Rev Immunol,2010,28(14):491-533.
  • 10Liu B,Ryer E J,Kundi R,et al.Protein kinase C-delta regulates migration and proliferation of vascular smooth muscle cells through the extracellular signal-regulated kinase 1/2[J].J Vasc Surg,2007,45(1):160-168.

二级参考文献65

  • 1Streb H, Irvine RF, Berridge M J, et al. Release of Ca^2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1, 4, 5-trisphosphate [J]. Nature, 1983, 306 (5938): 67-69
  • 2Putney JW Jr. A model for receptor-regulated calcium entry [J]. Cell Calcium, 1986, 7 (1): 1-12
  • 3Putney JW Jr ,Bird GS. The inositol phosphate-calcium signaling system in nonexcitable cells [J]. Endocr Rev, 1993, 14 (5): 610-631
  • 4Parekh AB, Pumey JW Jr. Store-operated calcium channels [J]. Physiol Rev, 2005, 85 (2): 757-810
  • 5Lewis RS. The molecular choreography of a store-operated calcium channel [J]. Nature, 2007, 446 (7133): 284-287
  • 6Zweifach A, Lewis RS. Mitogen-regulated Ca^2+ current of T lymphocytes is activated by depletion of intracellular Ca^2+ stores [J]. Proc Natl Acad Sci U S A, 1993, 90 (13): 6295-6299
  • 7Lewis RS, Cahalan MD. Mitogen-induced oscillations of cytosolic Ca^2+ and transmembrane Ca^2+ current in human leukemic [J]. T cells Cell Regul, 1989, 1 (1): 99-112
  • 8Hoth M, Penner R. Depletion of intracellular calcium stores activates a calcium current in mast cells [J]. Nature, 1992, 355 (6358): 353-356
  • 9Prakriya M, Lewis RS. CRAC channels: activation, permeation, and the search for a molecular identity [J]. Cell Calcium, 2003, 33 (5-6): 311-321
  • 10Liou J, Kim ML, Heo WD, et al. STIM is a Ca^2+ sensor essential for Ca^2+-store-depletion-triggered Ca^2+ influx [J]. Curr Biol, 2005, 15 (13): 1235-1241

共引文献17

同被引文献10

引证文献4

二级引证文献14

中国医学创新
2015年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部