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大肠癌组织中EGFR蛋白的表达及临床意义 被引量：1

The Expression of EGFR Protein in Colorectal Carcinoma and its Clinical Significance
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摘要 目的探讨EGFR蛋白在大肠癌组织中的表达及临床意义。方法使用免疫组化SP法检测EGFR蛋白在大肠癌组织中的表达。结果 EGFR蛋白阳性表达率在大肠癌组明显高于癌旁正常粘膜组(P<0.05);EGFR蛋白阳性表达与大肠癌淋巴结转移及临床分期(TNM)有关(P<0.05),而与大肠癌患者的性别、年龄及分化程度无关(P<0.05)。结论 EGFR蛋白的阳性表达与大肠癌的发生、发展、侵袭及转移有一定关系。 Objective To investigate the expression of EGFR protein in colorectal cancer tissues and its clinical signiifcance. Methods Using the expression of SP immunohistochemical method to detect EGFR protein in colorectal carcinoma tissues. Results EGFR protein positive expression rate was significantly higher than that of adjacent normal mucosa group in colorectal cancer group （P〈0.05）, the expression of EGFR protein in colorectal cancer and lymph node metastasis and clinical staging （TNM） on （P〈0.05）, but not in patients with colorectal cancer of sex, age and degree of differentiation （P〈0.05）. Conclusion Positive expression of EGFR protein has certain relationship with the occurrence and development, invasion and metastasis of colorectal cancer.
作者 刘淑娟 冯如新 李云喜 贺堃
机构地区 大连港医院消化内科
出处 《中国继续医学教育》 2015年第4期41-42,共2页 China Continuing Medical Education
关键词 大肠癌 EGFR蛋白 Colorectal cancer EGFR protein
分类号 R735.34 [医药卫生—肿瘤]
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参考文献5

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中国继续医学教育
2015年 第4期

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