骨髓间充质干细胞在脱细胞真皮基质再生过程中的初步研究

The Preliminary Study of Regeneration Process in Bone Marrow Mesenchymal Stem Cells on Acellular Dermal Matrix

较大的腹壁缺损需要应用补片修复来缓解腹横筋膜的张力,人工合成补片的应用一定程度上实现了无张力修补的目的,但它在腹壁外科应用中有诸多的并发症,诸如复发率高,腹腔黏连,肠穿孔导致腹膜炎,侵袭性肠瘘等影响患者术后的正常生活,而脱细胞真皮基质(Acellular dermal matrix,ADM)作为一种新型的生物材料应用在腹壁外科中能解决上述人工合成补片所带来的并发症发挥强大作用且能与周围组织较好的融合,最后改建成宿主自身组织已并在多学科领域中广泛应用;骨髓间充质干细胞(Bone marrow mesenchymal stem cells,BMSCs)能参与组织自我修复,并能分化成为多种功能细胞,分泌各种生长因子,在ADM内源性转归过程中可发挥作用。本文就对骨髓间充质干细胞在ADM生物补片应用于临床疝修补术中转归机制的研究做一综述。

To repair larger abdominal wall defects, there is need to use man-made patches of synthesis. Because, to some extent, their application can help reach the purpose of tensionless. The man-made pitches of synthesis have many complications used in Abdomi- nal wall surgery, such as high rate of relapse, intraperitoneal adhesion led to peritonitis, and invasive intestinal fistula, which affect the postoperative patients with normal life, but Acellular dermal matrix as a new kind of biological materials, can help solve those problems and can integrate with the organization well instead of man-made patches, even though in many different disciplines. Bone marrow mes- enehymal stem cells play an important role in participating tissue repair, secreting multiple cell growth factors. This review deseribes the preliminary study of the process of regeneration in Bone marrow mesenchymal stem cells on Acellular dermal matrix.