251例抗菌药物不良反应报告分析

ADR Report Analysis of 251 Cases Caused by Antimicrobial Drugs

目的:了解我院抗菌药物不良反应的分布状态,为临床合理用药提供参考。方法:对2009年1月-2013年12月的抗菌药物不良反应报告进行分类统计和分析评价。结果:我院使用的36种抗菌药物共报告药品不良反应251例,男性119例(47.41%),女性132例(52.59%)。50岁以上老年患者166例(66.14%),明显高于其他人群。严重病例16例(6.37%),一般病例235例(93.63%)。静脉给药242例(96.41%),口服给药9例(3.59%)。头孢菌素类引起的不良反应最多(135例,53.78%),青霉素类次之(79例,31.47%)。临床表现以皮肤及附件损害为主(129例,51.39%)。结论:应重视开展药品不良反应监测,促进抗菌药物合理应用。

Objective： To investigate the distribution of adverse drug reactions of antimicrobial drugs in our hospital so as to provide a reference for rational drug use in clinical practice . Methods：The adverse drug reactions of antimicrobial drugs reported from January 2009 to December 2013 were statistically analyzed and evaluated . Re-sults：About 36 kinds of antimicrobial agents were used in our hospital and 251 cases of adverse drug reactions were reported , including 119 male cases （ 47 . 41%） and 132 female cases （ 52 . 59%） , and 166 cases （ 66 . 14%） were over 50 years old , which was significantly higher than other groups . Of the 251 cases , 16 cases （ 6 . 37%） were in serious conditions , 235 cases （ 93 . 63%） were the general case . 242 cases （ 96 . 41%） received drugs intra-venously and 9 cases （ 3 . 59%） received drugs by oral administration . Most adverse drug reactions were caused by cephalosporins （ 135 cases , 53 . 78%） and penicillin （ 79 cases , 31 . 47%） . The main clinical manifestations were skin and appendage damage （ 129 cases , 51 . 39%） . Conclusion：It is necessary to pay more attention to ADR monitor-ing and to promote the rational use of antibacterial agents .