载脂蛋白B mRNA编辑酶催化多肽在肿瘤中的研究进展

Research process of apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like in tumors

载脂蛋白B mRNA编辑酶催化多肽（APOBEC）是一类RNA或DNA编辑蛋白,能够将胞嘧啶突变为尿嘧啶,在肝脏脂类运输、抗体多样性修饰、抗反转录病毒等多方面发挥重要生理作用.近年来有研究发现,APOBEC家族成员在乳腺癌、子宫颈癌、肺癌、肝癌等多种肿瘤组织中高表达,并能引起大量体细胞突变.文章就APOBEC蛋白家族及其在肿瘤中的研究进展作一综述.

Apolipoprotein B mRNA editing enzyme,catalytic polypeptide-like （APOBECs） is a group of cytidine deaminases,which represents somewhat unusual protein family that can insert mutations in DNA and RNA as a result of their ability to deaminate cytidine to uridine.APOBECs seem to have diverse roles,such as lipid transport,antigen-driven antibody diversification and acting an innate defense system against retroviruses.In recent years,other functions of APOBECs were identified.Notably,APOBECs can cause host genome mutations and are upregulated in multiple cancers,such as breast,cervix,lung,liver cancers and so on.The researches on APOBEC and its relations with in tumors were reviewed.