纳洛酮治疗慢性阻塞性肺疾病并Ⅱ型呼吸衰竭的效果观察

Observation of the effects of naloxon on chronic obstructive pulmonary disease and respiratory failure Ⅱ

目的探讨纳洛酮治疗慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭的临床治疗效果。方法选取信阳市第一人民医院2012年3月至2013年8月收治的84例慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭患者,将其分为两组,对照组42例采用常规对症治疗,观察组42例采用常规对症治疗加纳洛酮,观察两组患者的治疗效果和不良反应情况。结果观察组总有效率为92.9%,高于对照组的71.4%,且观察组的心脏指数、肺动脉压力、血气分析指标变化均明显优于对照组,差异有统计学意义(P<0.05)。结论纳洛酮治疗可提高慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭患者的治疗效果,且安全可靠,值得临床推广应用。

Objective To study the clinical effect of naloxone on chronic obstructive pulmonary disease combined with respiratory failure Ⅱ.Methods 84 patients with chronic obstrutive pulmonary disease and respiratory failure Ⅱ in the first people＇s hospital of Xinyang from March 2012 to August 2013 were selected and divided into two groups,42 patients in control group were given conventional treatment,and 42 patients in observation group were treated with conventional treatment and naloxone.The treatment effects and side effects of the patients in the two groups were observed.Results The total effective rate in treatment group was 90.7%,which was higher than that of the control group（71.4%）.The index changes of CI,pulmonary arterial pressure and blood gas analysis of the patients in observation group was obviously superior to that of the control group,and the differences were significant（P 〈0.05）.Conclusion Naloxone can improve the therapeutic effect of the patients with COPD and respiratory failure Ⅱ.It is safe,reliable and worthy of clinical popularization.