椎体成形术联合锶89内照射治疗椎体继发性恶性肿瘤的临床研究

Clinical research of percutaneous vertebroplasty combined with strontium-89 on patients with spinal malignant tumors

目的探讨经皮椎体成形术(PVP)序贯89锶核素(89 Sr)内照射治疗椎体继发性恶性肿瘤的临床疗效和价值。方法选择诊断明确的74例椎体继发性恶性肿瘤患者分成2组:对照组37例,仅接受PVP治疗;联合组37位,给予PVP联合89Sr内照射治疗,观察两组患者的治疗效果。结果联合组患者的生活质量、疼痛评分、肿瘤进展、生存期等疗效指标均明显优于对照组(P<0.05)。结论 PVP联合89Sr内照射治疗椎体继发性恶性肿瘤具有良好临床疗效和推广价值。

Objective This study aims to investigate the clinical value of percutaneous vertebroplasty（PVP）combined with strontium-89（89Sr）on patients with spinal malignant tumor.Methods Seventy four patients who were diagnosed as spinal malignant tumor were divided into two groups randomly.37 patients of the control group were treated by PVP only,and 37 patients of joint group were treated by PVP and 89 Sr together.Then the clinical effect of the joint group and control group was compared after treatment.Results After treatment,the quality of life,ratio of pain relief,clinical effect and survival time in joint group were distinctly better than control group（P〈0.05）.Conclusion PVP combined with 89 Sr can be an effective and safe treatment for patients with spinal malignant tumor.