奥卡西平和丙戊酸钠对癫痫患者血浆同型半胱氨酸和不对称二甲基精氨酸水平的影响

Effect of antiepileptic drugs on the level of plasma homocysteine and asymmetric dimethyl arginine in epileptic patients

目的探讨奥卡西平(OXC)和丙戊酸钠(VPA)对癫痫患者血浆同型半胱氨酸(Hcy)和不对称二甲基精氨酸(ADMA)水平的影响。方法分别检测OXC组32例和VPA组36例单药治疗的癫痫患者血浆Hcy和ADMA水平,与对照组比较,并分析Hcy和ADMA水平与抗癫痫药物治疗时间的相关性。结果 OXC组和VPA组患者血Hcy、ADMA水平高于对照组(P<0.05),OXC组和VPA组比较,差异无统计学意义(P>0.05);抗癫痫药治疗时间与血浆Hcy、ADMA水平均呈正相关(r=0.274、0.256,P<0.05)。结论 OXC和VPA可引起癫痫患者血浆Hcy、ADMA水平升高,长期服用OXC和VPA的癫痫患者应监测血Hcy、ADMA,及时补充B族维生素、叶酸有利于减少血栓事件的发生。

Objective To investigate plasma homocysteine（Hcy）and asymmetric dimethyl arginine（ADMA）concentration in patients with epilepsy receiving oxcarbazepine（OXC）or sodium valproate（VPA）monotherapy.Methods Plasma were collected from 32 cases of OXC and 36 cases of VPA monotherapy.The levels of hcy and ADMA were detected and compared with healthy controls.Then the correlation of the levels and antiepileptic drug treatment duration was analyzed.Results The levels of hcy and ADMA in treatment groups were higher than in control gruops（P〈0.05）,and no difference between two treatment groups（P〉0.05）.Antiepileptic drug treatment duration and plasma Hcy,ADMA levels were positively correlated（r=0.274,P〈0.05;r=0.256,P〈0.05）.Conclusion OXC and VPA elevated hcy and ADMA plasma levels in patients with epilepsy.Routine monitoring of plasma hcy and ADMA and supplementation of B vitamins and folate acid might have help to reduce thrombotic events occurring for patients receiving long-term OXC and VPA therapy.