2,6-二溴-4-甲基乙酰苯胺的一步合成

The Synthesis Research of N-( 2,6-dibromo-4-methylphenyl)acetamide via Cascade Reaction

研究了2,6-二溴-4-甲基乙酰苯胺的一步合成反应,优化了合成的条件。通过增加加热时间及蒸馏步骤,使得串联反应得以发生,从而获得最终的目标产物。筛选的最佳合成条件:以4-甲基苯胺为原料,经过溴代反应、加热酰化利用溶剂乙酸直接获得氨基保护的最终产物,产率高达93%。

Synthesis condition research of N-（ 2,6- dibromo- 4- methylphenyl） acetamide was investigated. The best reaction condition was generated cascade reaction with bromination reaction followed by acetylation reaction in acetic acid at 93% yield. The convenient cascade reaction process caused the reaction to be accelerated.