肠道微生物对宿主免疫系统的调节及其可能机制

Regulation of Host Immune System by Gut Microbiota and Its Possible Mechanisms

动物肠道是一个开放的生态系统,栖息着大量的微生物,这些微生物与宿主免疫系统之间协同进化,在维持肠道稳态方面发挥着重要的作用。建立和维持肠道微生物与宿主免疫系统之间有益的相互作用是保障机体健康的关键。为此,本文综述了肠道微生物区系的组成及影响因素、肠道微生物促进宿主免疫系统的发育及调节机体免疫系统的可能机制。

An animal gut is an open ecological system that is colonized by large numbers and variety of micro-organisms. The microbiota has coevolved relationship with the host immune system and plays an important role in maintaining intestinal homeostasis. Establishing and maintaining beneficial interactions between gut microbio-ta and host immunity are key requirements for host health. Therefore, this article reviewed the composition of gut microbiota, the development of the host immune system under regulation of gut microbes and the possible mechanisms of gut microbiota regulating immune system.