双相障碍患者胰岛素抵抗的研究

Study of insulin resistance in patients with bipolar disorder

目的:探讨不伴糖尿病的双相障碍(BD)患者糖代谢水平。方法:对111例BD患者(BD组)及41名正常对照者(NC组)进行体质量指数(BMI)、空腹血糖、胰岛素及糖化血红蛋白水平测定,计算胰岛素抵抗指数(IR);分析影响BD患者糖代谢的因素。结果:BD组空腹胰岛素(6.5 vs 4.3 ug/ml,P<0.001)、IR(0.9 vs 0.7,P=0.002)及IR发生率(44.1%vs 22.4%,P=0.027)显著高于NC组;在控制BMI因素后,BD组与NC组IR发生率差异无统计学意义。结论:不伴糖尿病的BD患者高胰岛素血症及IR发生率高,肥胖影响BD患者的糖代谢。

Objective： To evaluate the glucose metabolic levels in no comorbid diabetes patients with bipolar disorder（ BD） Method： The body mass index（ BMI）,the levels of fasting plasma glucose,insulin and glycosylated hemoglobin were detected in 111 BD patients without diabetes（ BD group） and 41 normal controls（ NC group）. The insulin resistance index（ IR） was calculated and the affecting factors of sugar metabolism in BD patients was analyzed. Results： In the BD group,the levels of fasting plasma insulin（ 6. 5 vs 4. 3 ug / ml,P〈0. 001）,IR（ 0. 9 vs 0. 7,P = 0. 002） and incidence of IR（ 44. 1% vs 22. 4%,P = 0. 027） were significantly higher than those in the NC group. The difference of IR incidence between the two groups was disappeared after the factor of BMI was controlled. Conclusion： The incidences of hyperinsulinemia and IR in BD patients without diabetes are prevalent. Obesity affects sugar metabolism in BD patients.