注意缺陷多动障碍患儿事件相关电位N400研究

Study on event related potentials N400 in children with attention deficit and hyperactivity disorder

目的:探讨注意缺陷多动障碍(ADHD)患儿汉语句子结尾词匹配和非匹配语言时相关电位(ERP)N400的变化。方法:应用ERP仪,采用汉语正常句子结尾词匹配与非匹配的范式,对35例ADHD患儿(ADHD组)和41名正常儿童(正常对照组)进行视觉诱发电位N400检测。结果:在Cz脑区匹配及非匹配条件下,ADHD组N400潜伏期[(384±45)ms,(436±35)ms]比正常对照组[(348±32)ms,(399±29)ms]显著延迟(P均<0.01);波幅ADHD组[(4.2±4.5)μV,(7.5±5.1)μV]显著低于正常对照组[(7.6±5.0)μV,(12.4±6.5)μV](P均<0.01)。结论:ADHD患儿N400异常,N400检测可能成为判断注意缺陷多动障碍的客观指标。

Objective： To explore the changes of event related potentials（ ERP） N400 elicited by Chinese sentences ending with matching or mismatching words in attention deficit and hyperactivity disorder（ ADHD）.Method： By ERP instruments,ERP component N400 were recorded in 35 children with ADHD（ ADHD group） and 41 normal controls（ NC group）,in a paradigm of Chinese sentences ending with matching or mismatching words. Results： In Cz areas and in congruent and incongruent situation,the N400 latencies in the ADHD group[（ 384 ± 45） ms,（ 436 ± 35） ms） were significantly prolonged than those in the NC group[（ 348 ±32） ms,（ 399 ± 29） ms]（ all P〈0. 01）; the N400 amplitudes in the ADHD group[（ 4. 2 ± 4. 5） μV,（ 7. 5 ±5. 1） μV] were significantly lower than those in the NC group [（ 7. 6 ± 5. 0） μV,（ 12. 4 ± 6. 5） μV]（ all P〈0. 01）. Conclusion： N400 abnormalities exist in ADHD patients,and N400 may be served as an objective index for diagnosis for ADHD in the future.