摘要
Brachyury是T-box转录因子家族的重要成员,与肿瘤发展密切相关,在肿瘤上皮-间质转化(epithelial-mesenchymal transition,EMT)中发挥重要作用,可能成为肿瘤免疫治疗的潜在靶点。从Brachyury与肿瘤转移、分期、预后的关系,对肿瘤EMT的诱导调节,对肿瘤传统治疗的抵抗及靶向Brachyury的肿瘤免疫治疗等方面进行了综述,并展望了Brachyury未来的研究方向和临床应用前景。
Brachyury is a founding member of T-box transcription factor family. Recently, accumulating evidence demonstrated that Brachyury is closely related to tumor progression, and plays a key role in the process of epithelial-mesenchymal transition (EMT), suggesting Brachyury may be a potential target for T cell- mediated immunotherapy of cancer. This review summarized the relationship between Brachyury and tumor metastasis, staging, and prognosis, the induction and regulation of EMT mediated by Brachyury, and the role of Brachyury in the resistance to traditional therapy of cancer and cancer immunotherapy targeting Brachyury. It also gived fresh perspectives on further investigation and clinical application of Brachyury.
出处
《生命科学》
CSCD
2015年第2期135-142,共8页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(81372511
81073103
30872944)
广东省自然科学基金项目(S2012010008232)
广东省产业技术研究与开发专项资金(2013B031100002)
广东省高等学校高层次人才资助项目:2011年广东省高等学校人才引进专项资金(2050205)
湛江市财政资金科技专项竞争性分配资助项目(2012C0303-56)
国家留学基金地方合作资助项目(201308440331)