细胞自噬与肿瘤的关系研究进展

Research progress on the relationship between autophagy and tumorigenesis

细胞自噬(autophagy)在肿瘤的发生发展过程中扮演着非常重要的角色。自噬作用是细胞的一种自我保护机制,是真核细胞用于清除细胞内聚物及受损细胞器,进而维持细胞内稳态的一种蛋白质降解途径。从细胞自噬的类型及其形成,细胞自噬的分子调控机制,自噬对肿瘤发生及发展、以及治疗耐药等恶性行为的影响,肿瘤中自噬与预后的关联,干预自噬对肿瘤治疗的影响和细胞自噬的研究方法等方面进行综述,以期为肿瘤的治疗提供新思路。

Autophagy plays an important role in the occurrence and development of tumor. Autophagy is one of self-protective mechanisms, and it is one of protein degradation pathways through removing polymer and damaged organelles to maintain cellular homeostasis. In this review, we mainly summarized the types of autophagy and its formation, the molecular regulation mechanism, the effects of autophagy in cancer development and drug resistance, the correlation between autophagy and prognosis in tumor, the effects of intervention of autophagy in tumor therapy and the research methods about autophagy, which may provide some new ideas for the treatment of tumor.