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MHCI类分子四聚体技术的应用研究进展 被引量：1

Progress on the application of the MHC I tetramer technology
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摘要 主要组织相容性复合体(major histocompatibility complex,MHC)I类分子四聚体(tetramer)技术可直接对抗原特异性细胞毒性T淋巴细胞(cytotoxic T lymphocytes,CTL)进行标记,以检测能够识别特定抗原肽-MHC I的CTL,用于临床检测、疾病诊断及相关科学研究。综述了MHC I四聚体技术应用的最新研究进展,为开展四聚体的相关研究提供新的参考。 The tetramer technology in major histocompatibility complex class I （MHC I） can be used to label the antigen-specific cytotoxic T lymphocytes （CTLs） directly so as to detect the CTLs, which can recognize the specific antigenic peptide-MHC I. The MHC I tetramer technology can be applied in clinical test, disease diagnosis and scientific research. In this article, the novel progress on the application of the MHC I tetramer technology is reviewed fully to provide a new reference to research in tetramer.
作者 董宋鹏 李子彬 杨杰 高凤山
机构地区 大连大学生命科学与技术学院 吉林农业大学生命科学学院
出处 《生命科学》 CSCD 2015年第2期228-233,共6页 Chinese Bulletin of Life Sciences
基金 国家自然科学基金项目(31172304)
关键词 MHC I 四聚体 抗原肽 细胞毒性T淋巴细胞 MHC I tetramer antigenic peptide cytotoxic T lymphocytes
分类号 R392.11 [医药卫生—免疫学]
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参考文献41

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二级参考文献29

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生命科学
2015年 第2期

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