摘要
主要组织相容性复合体(major histocompatibility complex,MHC)I类分子四聚体(tetramer)技术可直接对抗原特异性细胞毒性T淋巴细胞(cytotoxic T lymphocytes,CTL)进行标记,以检测能够识别特定抗原肽-MHC I的CTL,用于临床检测、疾病诊断及相关科学研究。综述了MHC I四聚体技术应用的最新研究进展,为开展四聚体的相关研究提供新的参考。
The tetramer technology in major histocompatibility complex class I (MHC I) can be used to label the antigen-specific cytotoxic T lymphocytes (CTLs) directly so as to detect the CTLs, which can recognize the specific antigenic peptide-MHC I. The MHC I tetramer technology can be applied in clinical test, disease diagnosis and scientific research. In this article, the novel progress on the application of the MHC I tetramer technology is reviewed fully to provide a new reference to research in tetramer.
出处
《生命科学》
CSCD
2015年第2期228-233,共6页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(31172304)