川崎病冠脉损伤与血清巨噬细胞炎症蛋白-1α水平的相关性

Relationship between coronary artery lesion in Kawasaki disease and macrophage inflammatory protein-1α level

目的探讨血清巨噬细胞炎症蛋白-1α(MIP-1α)水平与川崎病(KD)冠脉损伤的相关性。方法选取急性期KD患儿40例,其中15例有冠脉损伤,正常对照组20例。采用酶联免疫法(ELISA)检测血清MIP-1α水平,超声心动图检测冠状动脉扩张程度,分析血清MIP-1α水平变化及其与冠状动脉扩张程度的相关性。结果 KD急性期患儿的血清MIP-1α水平为(79.16±11.54)ng/L,高于正常对照组(38.16±5.21)ng/L,差异有统计学意义(P<0.05);冠脉损伤KD患儿的MIP-1α水平为(89.14±10.52)ng/L,高于无冠脉损伤KD患儿(71.15±2.48)ng/L,差异有统计学意义(P<0.05)。KD患儿血清MIP-1α水平与冠状动脉扩张程度呈正相关(r=0.438,P<0.05)。结论 KD急性期患儿的血清MIP-1α水平明显升高,伴有冠状动脉损伤的KD患儿的水平更高;血清MIP-1α水平与冠状动脉扩张程度呈正相关。

Objective To investigate the relationship between serum MIP-1α level and coronary artery lesion in Kawasaki disease （KD）. Methods The levels of serum MIP-1α from 40 KD patients （including 15 patients with coronary artery lesion） and 20 healthy children were detected by enzyme-linked immunosorbent assay. The degree of coronary artery dilatation was detected by ultrasonic cardiogram and its association with MIP-1α was analyzed. Results The level of serum MIP-I a in acute KD patients （79.16± 11.54） ng/L was significantly higher than that in healthy children （38.16±5.21） ng/L （P〈0.05）. The level of serum MIP-1 a in acute K_D patients with coronary artery lesion （89.14＋ 10.52） ng/L was higher than in KD patients with non-coronary artery dilatation （71.15±2.48） ng/L （P〈0.05）. In addition, the level of serum MIP-1α in KD patients showed positive correlation with the degree of coro- nary artery dilatation （r=0.438, P〈0.05）. Conclusion The level of serum MIP-1α is significantly higher in KD patients and further higher in KD patients with coronary artery lesion. The serum MIP-1α level in KD patients shows a positive correlation with the degree of coronary artery dilatation.