摘要
目的探讨血清巨噬细胞炎症蛋白-1α(MIP-1α)水平与川崎病(KD)冠脉损伤的相关性。方法选取急性期KD患儿40例,其中15例有冠脉损伤,正常对照组20例。采用酶联免疫法(ELISA)检测血清MIP-1α水平,超声心动图检测冠状动脉扩张程度,分析血清MIP-1α水平变化及其与冠状动脉扩张程度的相关性。结果 KD急性期患儿的血清MIP-1α水平为(79.16±11.54)ng/L,高于正常对照组(38.16±5.21)ng/L,差异有统计学意义(P<0.05);冠脉损伤KD患儿的MIP-1α水平为(89.14±10.52)ng/L,高于无冠脉损伤KD患儿(71.15±2.48)ng/L,差异有统计学意义(P<0.05)。KD患儿血清MIP-1α水平与冠状动脉扩张程度呈正相关(r=0.438,P<0.05)。结论 KD急性期患儿的血清MIP-1α水平明显升高,伴有冠状动脉损伤的KD患儿的水平更高;血清MIP-1α水平与冠状动脉扩张程度呈正相关。
Objective To investigate the relationship between serum MIP-1α level and coronary artery lesion in Kawasaki disease (KD). Methods The levels of serum MIP-1α from 40 KD patients (including 15 patients with coronary artery lesion) and 20 healthy children were detected by enzyme-linked immunosorbent assay. The degree of coronary artery dilatation was detected by ultrasonic cardiogram and its association with MIP-1α was analyzed. Results The level of serum MIP-I a in acute KD patients (79.16± 11.54) ng/L was significantly higher than that in healthy children (38.16±5.21) ng/L (P〈0.05). The level of serum MIP-1 a in acute K_D patients with coronary artery lesion (89.14+ 10.52) ng/L was higher than in KD patients with non-coronary artery dilatation (71.15±2.48) ng/L (P〈0.05). In addition, the level of serum MIP-1α in KD patients showed positive correlation with the degree of coro- nary artery dilatation (r=0.438, P〈0.05). Conclusion The level of serum MIP-1α is significantly higher in KD patients and further higher in KD patients with coronary artery lesion. The serum MIP-1α level in KD patients shows a positive correlation with the degree of coronary artery dilatation.
出处
《海南医学》
CAS
2015年第3期342-344,共3页
Hainan Medical Journal
关键词
川崎病
冠状动脉
巨噬细胞炎症蛋白-1Α
Kawasaki disease
Coronary artery
Macrophage inflammatory protein-1α