基于PET-CT靶区勾画在食管癌放疗中的应用价值

Application of PET-CT in the target delineation of radiotherapy of esophageal cancer

目的探讨派特CT(PET-CT)在食管癌放疗靶区勾画中的应用价值。方法选取2013年1月至2014年1月收治的60例食管癌患者为研究对象,根据其放疗靶区勾画方式的不同分为对照组(以CT进行定位及勾画放疗靶区)30例和观察组(以PET-CT进行定位及勾画放疗靶区)30例,比较两组患者放射性肺损伤发生率及放射治疗前和放射治疗后1周、2周、4周、6周的血清转化生长因子-β1(TGF-β1)、肿瘤坏死因子α(TNF-α)、白介素1β(IL-1β)及基质金属蛋白酶12(MMP-12)水平。结果观察组中不同部位病灶者的放射性肺损伤发生率均低于对照组,放射治疗后1周、2周、4周、6周的血清TGF-β1、TNF-α、IL-1β及MMP-12水平均高于对照组,两组患者之间比较差异均有统计学意义(P<0.05)。结论 PET-CT在食管癌放疗靶区勾画中的应用价值较高,可有效降低放疗对患者造成的不良影响。

Objective To study and observe the application value of Positron Emission Tomography-Computed Tomography（PET-CT） in the target delineation of radiotherapy of esophageal cancer. Methods Sixty patients with esophageal cancer from January 2013 to January 2014 were selected as research objects, and they were divided into control group（CT group, 30 cases） and observation group（PET-CT group, 30 cases） according to different target delineation methods of radiotherapy. Then the radiation-induced lung injury rates, serum transforming growth factor-β1（TGF-β1）, tumor necrosis factor α（TNF-α）, interleukin 1β（IL-1β）, and matrix metalloproteinase12（MMP-12） before radiotherapy and 1, 2, 4, 6 weeks after radiotherapy of two groups were analyzed and compared, respectively. Results The radiation-induced lung injury rates of observation group with different parts of lesions were lower than those of control group. Serum TGF-β1, TNF-α, IL-1β and MMP-12 1, 2, 4 and 6 weeks after radiotherapy were all higher than those of control group. The differences were all statistically significant（P〈0.05）.Conclusion The application value of PET-CT in the target delineation of radiotherapy of esophageal cancer is high,and it can effectively decrease the bad influence of radiotherapy for the patients.