慢性低氧性肺动脉高压血管重塑机制的研究进展

Research advance on chronic hypoxic pulmonary hypertension revascularization mechanism

慢性缺氧是许多呼吸系统疾病常见的病理和生理过程。低氧性肺动脉高压是一种长期暴露在低氧环境中所诱发的渐进性、复杂性病变,它最终导致不可逆转的右心衰竭,因此成为临床治疗的难点。肺血管重塑是肺动脉高压不断进展的病理基础,亦是多种药物治疗不理想的根源。肺血管重塑机制复杂,其中涉及到多种细胞分子和信号通道的分别和相互作用,对其全面了解有着重要的意义。本文就目前的研究现状和研究前景做一综述。

Chronic hypoxia is a common pathological and physiological characteristic of many respiratory diseases. A long-time exposure in the low oxygen environment could induce hypoxic pulmonary hypertension （HPH）, which is a progressive and complex process. And it became a difficult point of clinical treatment for its leading to an irreversible right heart failure. Hypoxia-induced pulmonary vascular remodeling is the pathological basis of progressive HPH and the main reason for the dissatisfied drug treatment. It is of great significance for a further study of the cellular and molecular mechanisms of hypoxia-induced remodeling which showed a highly complex process where numerous interactive events existed. And the review herewith provides a summary on the research status and its prospects.