ODC和CD_(105)在良性、癌前和恶性外阴肿瘤中的表达及意义

Expression and significance of ODC and CD_(105) in benign, precancerous and malignant vulvar tumors

目的探讨鸟氨酸脱梭酶(Ornithine decarboxylase,ODC)和CD105蛋白(Cluster of differentiation105,CD105)在外阴癌变中的作用。方法选取30例外阴鳞癌、30例外阴上皮内瘤变和30例外阴正常表皮,采用免疫组化的方法进行研究。分析ODC和CD105表达与外阴鳞癌的临床病理特征。结果 ODC和CD105在正常外阴组织中的阳性率明显低于外阴上皮内瘤变组织和外阴鳞癌组织,而于外阴上皮内瘤变组织中的阳性率明显低于外阴鳞癌组织,差异均有显著统计学意义(P<0.01),ODC与细胞分化程度密切相关(P<0.05),CD105与临床分期和淋巴转移密切相关(P<0.05)。结论 ODC和CD105在外阴鳞癌发生和发展中具有重要的意义。

Objective To discuss the role of ornithine decarboxylase（ODC） and cluster of differentiation105（CD105） in vulvar tumor. Methods Thirty cases of malignant vulvar tumors, 30 cases of vulvar intraepithelial neoplasia, and 30 cases of normal vulvar tissue were studied by immunohistochemistry. ODC and CD105 expression and clinical pathological features of vulvar squamous carcinoma were further analyzed. Results The positive expression rate of ODC and CD105 in normal vulvar tissues was significantly lower than that in the genital intraepithelial neoplasia and squamous cell carcinoma of the vulva, and the positive rate in vulvar intraepithelial neoplasia was significantly lower than that in vulvar squamous cell carcinoma tissue, with statistically significant difference（P〈0.01）. ODC was closely related to the degree of cell differentiation（P〈0.05）, and CD105 was closely related to clinical stage and lymph node metastasis（P〈0.05）. Conclusion ODC and CD105 had vital significance in the development of vulvar squamous carcinoma（HCC）.