溃疡性结肠炎患者血清NGAL检测及意义

Clinical Significance of Serum Neutrophil Gelatinase-associated Lipocalin in Patients with Ulcerative Colitis

目的探讨溃疡性结肠炎(UC)患者血液中NGAL的含量和意义。方法使用胶乳增强免疫比浊法检测89例UC患者血清中NGAL含量并与对照组比较。分析NGAL水平与UC患者WBC数量、PLT数量、CRP和Hgb、HCT、ESR、年龄、疾病活动程度(DAI)关系。结果 UC患者血清中NGAL水平显著高于健康对照组,中位数分别为112ng/m L和48.2ng/m L,差异有统计学意义(P<0.0001)。血清NGAL水平在轻度和中、重度UC患者血清NGAL中位数分别为78.2ng/m L和67.2ng/m L,差异有统计学意义(t=3.981,P=0.006)。UC患者血清NGAL水平与WBC数量、PLT数量、CRP和Hgb、HCT、ESR、年龄无关(P>0.05),与疾病活动程度(DAI)轻度相关(r=0.525,P<0.0001)。结论溃疡性结肠炎患者血清NGAL水平升高,升高水平与疾病活动程度有关,但是其在疾病中的作用尚需进一步研究。

Objective To explore the clinical significance of serum neutrophil gelatinase-associated lipocalin（ NGAL） in patients with ulcerative colitis（ UC）. Methods The serum NGAL in 89 patients with UC and healthy controls were measured by using latex-enhanced immunoturbidimetric assay. The correlation between serum NGAL and blood WBC counts,PLT counts,CRP,Hgb,HCT,ESR,age,disease activity index（ DAI）were analyzed. Results The serum NGAL levels in UC patients were markedly higher than that of the controls（ P 〈 0. 0001）. The serum NGAL levels in mild UC group were obviously lower than that in moderate-severe UC group（ 78. 2 vs 67. 2ng / m L,P = 0. 006）. There was no correlation between serum NGAL in UC patients and WBC counts,PLT counts,CRP,Hgb,HCT and ESR,age（ P 〉 0. 05）. The serum NGAL levels in UC patients was mildly positively correlated with disease activity index（ r = 0. 525,P 〈 0. 0001）. Conclusion The serum NGAL level in patients with UC is elevated and related with DAI,but its role in patients with UC needs to be further studied.