超声波促进手性双酰基氧化膦的合成

Synthesis of chiral bisacylphosphine oxide under ultrasonic wave irradiation

以L-薄荷醇为原料,经3步反应制备得到中间体薄荷基二氯化膦.该中间体首先通过与超声波辐射制备的微米级钠粒反应形成薄荷基膦二钠盐,然后依次经过偶联及氧化反应合成了目标产物(-)-双(薄荷基甲酰基)薄荷基氧化膦(BMMPO),并经过1 H NMR、13 C NMR、31P NMR和元素分析进行了表征.

With L‐menthol as raw material ,menthyldichlorophosphine intermediate was pro‐duced by a three‐step reaction .At first ,the intermediate was allowed to react with sodium mi‐cron particle ,which was produced by ultrasonic irradiation ,to give disodium menthylphos‐phide ,and coupling and oxidating of the resulted disodium menthylphosphide to give the target compound （‐）‐bis （menthyl‐formyl） menthylphosphine oxide （BMM PO ） .The structure was characterized by 1 H NMR , 13 C NMR , 31 P NMR and elemental analysis .