奥硝唑注射液致固定性药疹1例

One case of fixed drug eruption caused by ornidazole injection

1例80岁女性患者1年前行胆囊切除术,近日因胆道感染、反流性食管炎、冠状动脉粥样硬化性心脏病等入院治疗。给予奥硝唑注射液(0.5 g,bid,ivgtt)和头孢曲松(2 g,qd,ivgtt)进行抗感染,奥美拉唑钠(40 mg,bid,ivgtt)抑制胃酸治疗。用药第4天,患者双足出现多个水疱样固定性药疹。立即停用奥硝唑注射液,口服氯雷他定片(10 mg,qd),同时外用卤米松膏,抽疱湿敷治疗7 d后,患者双足固定性药疹结痂好转。

One 80-year-old female patient was hospitalized for biliary tract infection, reflux esophagitis, coronary atherosclerosis heart disease after cholecystectomy surgery 1 year ago. Omidazole injection （0.5 g, bid, ivgtt） and ceftriaxone （2 g, qd, ivgtt） were used for anti-infection, omeprazole sodium （40 mg, bid, ivgtt） was utilized for gastric acid inhibition. On the fourth day, a few vesicular fixed drug eruptions occurred on the patient＇s feet. Ornidazole injection was stopped immediately, loratadine （10 mg, qd） and halometasone ointment were given. Suction blisters and wet for 7 days, the fixed drug eruption on the patient＇s feet began to escharosis and improved.