血管内皮及其分泌因子在血压调节中作用机制

Vascular Endothelial and Secreted Factor in Mechanism of Blood Pressure Regulation

高血压是危害人类健康的主要疾病,可导致心脑肾及其他血管系统的病变。目前我国有2.5亿高血压患者,成人患病率为25%-30%,高血压的防治及研究需要不断深入。血管内皮在调节血流和血压方面发挥着重要作用,高血压患者存在血管内皮功能损伤,而内皮功能异常加速高血压进程及其靶器官损害,同时促进动脉粥样硬化的发生发展。该文对血管内皮及其分泌的因子在血压调节中的作用机制进行概述。

Hypertension is a major disease harmful to human health and can lead to cardiovascular and renal diseases and other vascular system diseases. At present,our country has 250 million hypertensive patients and the adult prevalence rate is 25%-30%. Its prevention and treatment needs further study. The vascular endothelium plays an important role in regulation of blood flow and blood pressure and the endothelial dysfunction exists in hypertensive patients and endothelial dysfunction accelerates the progress of hypertension and target organ damage and promotes the development of atherosclerosis. This paper outlined the mechanisms of vascular endothelium and its secretory factors in blood pressure regulation.