锌-α2-糖蛋白与体脂

Relationship between zinc α2 glycoprotein and body fat

锌-α2-糖蛋白(zincα2 glycoprotein,ZAG)是一种新的脂肪因子,它能促进脂肪分解代谢。ZAG与体脂存在一定的联系:恶病质患者体脂减少,血清ZAG浓度显著升高;肥胖患者体脂增多,血清ZAG水平比正常人低;在一些疾病状态下ZAG表达上调,引起体脂下降。本文就不同状态下体脂与ZAG表达之间的关系进行综述。

Zinc α2 glycoprotein （ZAG） is a novel adipokine that can induce lipolysis. There are some relationships between body fat and ZAG： cachexia patients are often accompanied with body fat loss, and increased serum ZAG level; for obese patients, body fat accumulates, and the serum ZAG level is lower than normal; with different disease status ZAG expression is up-regulated, inducing body fat loss. In this paper the relationships between body fat and ZAG expression under different cases are reviewed.