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AMPK促凋亡机制研究进展 被引量：2

Advances on the pro-apoptotic mechanims of AMPK
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摘要 腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)是调节细胞能量代谢的关键酶。近年来研究还发现AMPK可通过抑制p53降解、上调Bim表达、抑制m TOR活性及升高活性氧(ROS)水平等途径促进细胞凋亡。本文综述了近年来关于AMPK促细胞凋亡机制的研究进展。 AMP-activated protein kinase （AMPK） is a key enzyme in the regulation of cellular energy metabolism. Recent studies have also found that AMPK may promote cell apoptosis by inhibiting the degradation of p53, increasing the expression of Bim, inhibiting the activity of roTOR and increasing the level of ROS. The recent advances on the pro-apoptotic mechanims of AMPK have been reviewed in this paper.
作者 蔡帆 苏金玲 葛璞 艾青 张力
机构地区 重庆医科大学病理生理学教研室 重庆医科大学生理学教研室
出处 《生命的化学》 CAS CSCD 2015年第1期26-30,共5页 Chemistry of Life
基金 国家自然科学基金项目(81370179)
关键词 AMPK 凋亡 能量代谢 P53 肿瘤 AMPK apoptosis energy metabolism p53 tumor
分类号 Q255 [生物学—细胞生物学]
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参考文献35

  • 1Hardie DG. AMPK: positive and negative regulation, and its role in whole-body energy homeostasis. Curr Opin Cell Biol, 2014, 33: 1-7.
  • 2Okoshi R, Ozaki T, Yamamoto H, et al. Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress. J Biol Chem, 2008, 283: 3979-3987.
  • 3Nieminen Al, Eskelinen VM, Haikala HM, et al. Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis. Proc Natl Acad Sci USA, 2013, 110: 1839-1848.
  • 4Hardie DG. The AMP-activated protein kinase pathway-new players upstream and downstream. J Cell Sci, 2004, 117: 5479-5487.
  • 5Carling D. AMP-activated protein kinase: balancing the scales. Biochimie, 2005, 87: 87-91.
  • 6Kefas BA,Cai Y, Ling Z, et al. AMP activated protein kinase can induce apoptosis of insulin producing MIN6 cells through stimulation of c-Jun N-terminal kinase. J Mol Endocrinol, 2003, 30: 151-161.
  • 7Dagon Y, Avraham Y, Berry EM. AMPK activation regulates apoptosis, adipogenesis, and lipolysis by efF2a in adipocytes. Biochem Biophys Res Commun, 2006, 340: 43-47.
  • 8Garcia-Gil M,Pesi R, Perna S, et al. 5-aminoimidaz-ole-4-carboxamide riboside induces apoptosis in human neuroblastoma cells. Neuroscience, 2003, 117: 811-820.
  • 9Saitoh M, Nagai K, Nakagawa K, et al. Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathwauy relevant to activation of AMP-activated protein kinase. Biochem Pharmacol, 2004, 67: 2005-2011.
  • 10Kefas BA, Heimberg H, vaulont S, et al. AICA-riboside induces apoptosis of pancreatic p cells through stimulation of AMP-activated protein kinase. Diabetologia, 2003, 46: 250-254.

二级参考文献43

  • 1Perez-Castro R,Patel S,Garavito-Aguilar ZV,et al.Cytotoxicity of local anesthetics in human neuronal cells.Anesth Analg,2009,108 (3):997-1007.
  • 2Unami A,Shinohara Y,Ichikawa T,et al.Biochemical and microarray analyses of bupivacaine-induced apoptosis.J Toxicol Sci,2003,28(2):77-94.
  • 3Irwin W,Fontaine E,Agnolucci L,et al.Bupivacaine myotoxicity is mediated by mitochondria.J Biol Chem,2002,277 (14):12221-12227.
  • 4Cederroth CR,Vinciguerra M,Gjinovci A,et al.Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism.Diabetes,2008,57(5):1176-1185.
  • 5Park CJ,Park SA,Yoon TG,et al.Bupivacaine induces apoptosis via ROS in the Schwann cell line.J Dent Res,2005,84(9):852-857.
  • 6Kim WH,Lee JW,Suh YH,et al.AICAR potentiates ROS production induced by chronic high glucose:roles of AMPK in pancreatic β-cell apoptosis.Cell Signal,2007,19(4):791-805.
  • 7Cai Y,Martens GA,Hinke SA,et al.Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation.Free Radic Biol Med,2007,42(1):64-78.
  • 8Cantó C,Auwerx J.PGC-1α,SIRT1 and AMPK,an energy sensing network that controls energy expenditure.Gurr Opin Lipidol,2009,20(2):98-105.
  • 9McFadden JW,Corl BA.Activation of AMP-activated protein kinase (AMPK) inhibits fatty acid synthesis in bovine mammary epithelial cells.Biochem Biophys Res Commun,2009,390(9):388-393.
  • 10Claret M,Smith MA,Batterham RL,et al.AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons.J Clin Invest,2007,117(8):2325-2336.

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生命的化学
2015年 第1期

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