肿瘤防治新靶向:炎症和微生物

New targets of tumor therapy: inflammation and microbial communities

近年来,炎症逐渐成为相关肿瘤发生不可忽视的重要因素。研究发现:炎症诱导肿瘤的发生主要通路为NF-κB–IL6–STAT3途径,同时微生物和炎症介导的肿瘤发生之间也存在一定的联系。这些研究为癌症的治疗提供了新的理论基础,文章中阐述了NF-κB–IL6–STAT3通路在炎症诱导肿瘤发生中的重要作用以及引起相关炎症的微生物活动,提出了肿瘤治疗的新方向。

Recently, inflammation has become one of the most important factors that contribute to tumorigenesis. The NF-κB-IL6-STAT3 pathway plays a crucial role during the inflammation-induced cancer. Simultaneously, microbial communities may also participate in this process. These researches highlight the NF- κB-IL6-STAT3 pathway that causes the inflammation and microbe-associated cancer, and provide some new theories for targeted therapies.