同机PET／MR显像临床应用价值初探

Preliminary clinical application of hybrid PET/MR

目的回顾性探讨PET／MR在全身性肿瘤筛查、局部肿瘤显像及神经系统功能成像中的临床价值。方法共人组志愿者425例[男149例，女276例，年龄21∽82（平均56）岁]，其中全身性肿瘤筛查58例，局部肿瘤显像264例，神经系统功能成像103例，均行全身或局部18F—FDGPET／MR检查。结果58例PET／MR全身性肿瘤筛查结果阳性49例（84．48％），均为良性病变；局部肿瘤显像中，病灶阳性显示率（含34例18F。FDGPET阴性肿瘤患者）为100％（264／264），诊断准确性为95．45％（252／264），其中56例宫颈癌PET／MR的国际妇产科联盟（FIGO）分期诊断准确性为92．86％（52／56），46例鼻咽癌患者近期疗效评价CR率为69．57％（32／46）；103例神经系统功能成像中，92例（89．32％）PET／MR阳性诊断经手术及临床随访证实为真阳性。结论PET／MR一站式检查可显著提高疾病的显示及诊断的准确性，可为临床提供有价值的病变定位、定性、定量及功能信息。

Objective To retrospectively evaluate the clinical application of hybrid PET/MR in whole-body tumor screening, regional tumor imaging and central nervous system （CNS） functional imaging. Methods A total of 425 volunteers （149 males, 276 females, age： 21- 82 （mean 56） years） were en- rolled in this study, including 58 healthy subjects for whole-body PET/MR, 264 cases with tumors for re- gional PET/MR and 103 cases with CNS problems for CNS PET/MR. Results A total of 49 cases （84. 48%） undergoing whole-body PET/MR had positive results which were all proved to represent benign lesions. Regional PET/MR was positive in 100% of patients （264/264, 34 cases were XSF-FDG PET nega- tive）, and the diagnostic accuracy was 95.45% （252/264）. The accuracy for PET/MR staging in cervical carcinomas was 92.86% （52/56） and CR ratio of nasopharyngeal carcinomas was 69.57% （32/46）. CNS PET/MR was positive in 92 cases （89.32%） which were confirmed true positive by post-operative pathology and clinical follow-up. Conclusions PET/MR might improve lesion detection rate and diagnostic accuracy. It could provide accurate lesion localization, qualification, quantification and function assessment.