肝细胞核因子在卵巢透明细胞癌中的表达及其意义

The Expression and Significance of HNF-1β in Ovarian Clear Cell Carcinoma

目的研究肝细胞核因子(HNF-1β)在卵巢透明细胞癌中的表达及临床病理意义,探讨其对卵巢透明细胞癌的诊断价值。方法采用免疫组织化学方法检测35例卵巢透明细胞癌、65例卵巢高级别浆液性乳头状癌和30例卵巢子宫内膜样腺癌中HNF-1β的表达,比较HNF-1β在3种卵巢癌中的阳性表达率;同时观察3种卵巢癌中子宫内膜异位灶的例数,并比较HNF-1β的阳性表达情况。结果 HNF-1β在卵巢透明细胞癌中表达率为94.3%,其中高表达率88.5%;在高级别浆液性乳头状癌中表达率为46.2%,其中高表达率7.6%;在子宫内膜样腺癌中表达率为40%,无高表达。HNF-1β在卵巢透明细胞癌中的表达率特别是高表达率明显高于高级别浆液性乳头状癌和卵巢子宫内膜样腺癌(P<0.01);在卵巢透明细胞癌中子宫内膜异位灶的表达率为72.2%,明显高于卵巢子宫内膜样腺癌中子宫内膜异位灶的表达(P<0.01)。结论 HNF-1β高表达对卵巢透明细胞癌具有较为特异的诊断价值。

Objective To study the expression significance of HNF‐1βin ovarian clear cell carcino‐ma . Methods To detect the expression of HNF‐1β in 35 examples of ovarian clear cell carcinoma ,65 examples of high‐grade serous carcinoma and 30 examples of endometrioid carcinoma with immunohisto‐chemistry . Results HNF‐1β was expressed in 94 .2% ovarian clear cell carcinoma , strong intensity 88 .5% ;Expressed 46 .2% in high‐grade serous carcinoma ,strong intensity 7 .6% ;Expressed 40% in en‐dometrioid carcinoma ,strong intensity 0 ;The expression level of HNF‐1βin ovarian clear cell carcinoma are more obviously strongly than high‐grade serous carcinoma and endometrioid carcinoma （P〈0 .01） ,to possess statistic significance . The expression level of HNF‐1βin endometrioses in ovarian clear cell carci‐noma are more obviously strongly than endometrioid carcinoma （P〈 0 .01） ,to possess statistic signifi‐cance . Conclusions HNF‐1βhas a specific diagnosis value to ovarian clear cell carcinoma . HNF‐1βmay participate pathogenesis in endometriosis progress for the of ovarian clear cell carcinoma .