白血病动物模型研究进展

Research advances of the leukemia animal models

在研究治疗肿瘤的药物过程中,白血病动物模型常被选用。早期的白血病动物模型与人类白血病的拟合度不高,但随着对白血病发病机制研究的不断深入和技术的不断进步,白血病动物模型与人类白血病的拟合度明显改善。本文介绍几种白血病鼠类动物模型及研究进展。研究与人类白血病的拟合度高的动物模型对于抗癌药物的研发起着非常重要的作用。

Leukemia animal models are often used in the research of cancer drug.Early leukemia animal models had low degree of fitting to the condition of human leukemia.However,as the research of pathogenesis of leukemia developed,the degree of fitting is getting better.A few kinds of leukemia mouse models and their research advances are shown in this review.The research of the high similarity leukemia animal models will contribute to the improved understanding and treatment of these cancers.