摘要
目的探讨骨形成蛋白-7（BMP-7）在人类胃癌中的表达情况及临床意义。方法应用免疫组化方法检测210例胃癌组织中BMP-7的表达情况，分析BMP-7阳性表达与胃癌临床病理特征之间的关系。结果210例胃癌中116例BMP-7表达阳性（55％），BMP-7的表达与肿瘤直径、浸润深度、淋巴结受累、淋巴管侵犯、静脉侵犯和组织分型有有关（P〈0．01）。多元统计分析表明BMP-7的表达是-个独立的影响预后的因素，重要性仅次于浸润深度和淋巴结受累（P〈0．01）。结论BMP-7的自分泌或旁分泌可能调节了胃癌的进展过程，BMP-7的表达可以作为胃癌复发风险的-个重要预测指标。
Objective To investigate the expression of BMP - 7 in human gastric cancer. Methods The expres- sions of BMP -7 in gastric cancer tissues from 210 patients were measured using immunohistochemical method to analyze its relationship with the pathological characteristics of gastric cancer. Results The expression of BMP -7 was determined in 116 out of 210 gastric cancer samples （55 % ） , which was related with tumor size, nodal involvement, lymphatic inva- sion, venous invasion and tissue typing （P 〈 0.05）. According to muhivariate analysis, the expression of BMP - 7 was one of the independent prognostic factors, only secondary to the depth of invasion and nodal involvement （ P 〈 0.01 ）. Conclusion Autocrine/paracrine BMP -7 loops may regulate the progression of gastric cancer. The expression of BMP - 7 can act as one of the important predictors of recurrence risk in gastric cancer.
出处
《徐州医学院学报》
CAS
2014年第12期843-846,共4页
Acta Academiae Medicinae Xuzhou
