黄葵胶囊联合雷公藤多苷片治疗IgA肾病

Ambrette Capsules Combined Tripterygium Wilfordii Glycoside Tablets for IgA Nephropathy

目的探讨黄葵胶囊联合雷公藤多苷片治疗Ig A肾病的临床疗效。方法将84例Ig A肾病患者按治疗方法的不同分为2组:试验组和对照组,每组42例。2组均采用常规治疗,包括降尿酸、控制血脂和抗凝治疗及控制饮食、适当的运动锻炼。在此基础上,试验组采用黄葵胶囊联合雷公藤多苷片治疗,对照组采用雷公藤多苷片治疗。观察2组治疗前和治疗12周后总胆固醇(TC)、三酰甘油(TG)、血尿素氮(BUN)、血肌酐和24 h尿蛋白定量、尿视黄醇结合蛋白(RBP)和尿2-微球蛋白(2-MG)的变化及临床疗效、不良反应的情况。结果试验组总有效率明显高于对照组(P<0.05)。2组治疗12周后TC、TG、BUN及24 h尿蛋白定量、RBP和2-MG水平均较治疗前明显下降(P<0.05)。治疗12周后,试验组血肌酐水平较治疗前明显下降,TC、TG、BUN及24 h尿蛋白定量、RBP和2-MG水平均较对照组明显下降(均P<0.05),血肌酐水平较对照组无明显变化(P>0.05)。2组不良反应发生率比较差异有统计学意义(P<0.05)。结论雷公藤多苷片联合黄葵胶囊治疗Ig A肾病,能够明显提高临床疗效,降低尿蛋白水平,不良反应少。

Objective To explore the curative effect of ambrette capsules combined tripterygium wilfordii glycoside tablets on Ig A nephropathy. Methods Eighty-four patients with Ig A nephropathy received conventional therapy（lowering uric acid, lipid control, anticoagulation treatment, diet control and proper exercise）. In addition, these patients were treated with tripterygium wilfordii glycoside tablets alone（control group, n=42） or in combination with ambrette capsules（experimental group, n=42）. The total cholesterol（TC）, triacylglycerol（TG）, blood urea nitrogen（BUN）, serum creatinine, 24-hour urinary protein excretion, urinary retinol binding protein（RBP） and urinary 2-microglobulin（2-MG） were measured before and after treatment for 12 weeks. Furthermore, clinical efficacies and adverse reactions were observed in both groups. Results The total effective rate in experimental group was significantly higher than that in control group（P〈0.05）. The levels of TC, TG, BUN, 24-hour urinary protein excretion, RBP and 2-MG decreased in both groups and levels of serum creatinine decreased in experimental group after treatment for 12 weeks（P〈0.05）. Compared with control group, the levels of TC,TG, BUN, 24-hour urinary protein excretion, RBP and 2-MG levels decreased in experimental group after treatment for 12 weeks（P〈0.05）. No significant difference in levels of serum creatinine was found between the two groups（P〉0.05）. However, the difference in incidence of adverse reactions was significant between the two groups（P〈0.05）. Conclusion Ambrette capsules combined tripterygium wilfordii glycoside tablets can improve curative effect, decrease urine protein levels and reduce adverse reactions in patients with Ig A nephropathy.