320排螺旋CT灌注成像对小肝癌患者诊断价值的初步研究

Diagnostic Value of 320-Slice Spiral CT Perfusion Imaging in Patients with Small Hepatocellular Carcinoma

目的研究320排螺旋CT灌注成像对小肝癌患者的诊断价值。方法对10例经手术或活检证实的小肝癌患者的CT表现进行回顾性分析。应用最大斜率法计算小肝癌及肿瘤以外正常肝脏组织的肝动脉血流灌注量(HAF)、门静脉血流灌注量(HPF)及灌注指数(PI),并采用色阶赋值形成灌注影像,获取感兴趣区参数图。结果小肝癌的HAF、PI明显高于同一患者肝肿瘤以外的正常肝脏组织,HPF明显低于同一患者肝肿瘤以外的正常肝脏组织(均P<0.05)。结论 320排CT灌注成像扫描范围可以覆盖整个全肝,有效地显示小肝癌灌注参数值,对难以诊断的小肝癌提供了早期诊断的依据。

Objective To investigate the diagnostic value of 320-slice spiral CT perfusion imaging in patients with small hepatocellular carcinoma. Methods CT findings were analyzed retrospectively in 10 patients with small hepatocellular carcinoma confirmed by surgery or biopsy. The maximum slope method was used to calculate the hepatic arterial flow（ HAF）,hepatic portal flow（ HPF） and perfusion index（ PI） in small hepatocellular carcinoma and normal liver tissue. Furthermore,color maps for each perfusion parameter were displayed. Results Compared with normal liver tissue,the HAF and PI increased but HPF decreased in small hepatocellular carcinoma（ P〈0. 05）. Conclusion The 320-slice spiral CT whole-liver perfusion imaging can effectively display the perfusion parameters and provide a basis for early diagnosis of small hepatocellular carcinoma.