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从单细胞水平看肿瘤异质性 被引量：4

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摘要 在过去的二十多年里，很少有疾病像乳腺癌一样获得如此多的研究进展，特别是近年来，单细胞研究技术不断进步，掀起了肿瘤异质性研究的热潮。2012年，Gerlinger等的研究有力证实了肿瘤异质性的存在，随后，肿瘤异质性问题越来越多地被提及。对于临床医师而言，肿瘤异质性对临床工作和转化研究有哪些影响，本文将就此回顾最新进展，分享个人观点。
作者 盛湲 李恒宇
机构地区 第二军医大学长海医院甲状腺乳腺外科
出处 《中华乳腺病杂志（电子版）》 CAS 2014年第6期6-12,共7页 Chinese Journal of Breast Disease(Electronic Edition)
基金 中国博士后科研基金面上项目(2014M552624)
关键词 肿瘤异质性 单细胞水平 质性研究 临床医师 临床工作 乳腺癌
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献42

  • 1Gerlinger M, Rowan A J, I-Iorswell S, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing[J]. N Engl J Med, 2012, 366(10): 883-892.
  • 2Almendro V, Marusyk A, Polyak K. Cellular heterogeneity and molecular evolution in cancer[ J]. Annu Rev Pathol, 2013, 8: 277 -302.
  • 3杨壹羚,范宇,郎荣刚,谷峰,付丽.乳腺癌HER2基因遗传异质性与其临床病理特征的相关性研究[J].中华医学遗传学杂志,2010,27(5):540-545. 被引量：9
  • 4Sottoriva A, Spiteri I, Piecirillo SG, et al. Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics[J]. Proe Nafl Acad Sci U S A, 2013, 110(10): 4009-4014.
  • 5Wolff AC, Hammond ME, Hicks DG, et al. Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update [ J ]. Arch Pathol Lab Med, 2014, 138(2) : 241-256.
  • 6Xia L, Wang L, Chung AS, et al. Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation[ J]. J Biol Chem, 2002, 277(34) : 30716-30723.
  • 7Kreso A, O' brien CA, van Galen P, et al. Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer[ J ]. Science, 2013, 339 (6119) : 543-548.
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  • 9杨壹羚,褚嘉祐,王明荣.肿瘤遗传异质性[J].遗传,2013,35(1):1-9. 被引量：16
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二级参考文献96

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共引文献25

同被引文献57

  • 1尹预真,周菊英.乳腺癌术后肝转移34例相关性因素分析[J].南通大学学报（医学版）,2009,29(1):44-45. 被引量：2
  • 2王佳玉,徐兵河,田丽军,王燕.乳腺癌肝转移的临床病程与预后分析[J].中华肿瘤杂志,2006,28(8):612-616. 被引量：12
  • 3朱美琴,张东生,苏争艳,史艳侠,彭柔君,周宁宁,刘冬耕,姜文奇.98例乳腺癌肝转移患者的回顾性研究分析[J].癌症,2007,26(4):423-426. 被引量：6
  • 4Gerlinger M, Rowan A J, I-Iorswell S, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing[J]. N Engl J Med, 2012, 366(10): 883-892.
  • 5Almendro V, Marusyk A, Polyak K. Cellular heterogeneity and molecular evolution in cancer[ J]. Annu Rev Pathol, 2013, 8: 277 -302.
  • 6Sottoriva A, Spiteri I, Piecirillo SG, et al. Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics[J]. Proe Nafl Acad Sci U S A, 2013, 110(10): 4009-4014.
  • 7Wolff AC, Hammond ME, Hicks DG, et al. Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update [ J ]. Arch Pathol Lab Med, 2014, 138(2) : 241-256.
  • 8Xia L, Wang L, Chung AS, et al. Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation[ J]. J Biol Chem, 2002, 277(34) : 30716-30723.
  • 9Kreso A, O' brien CA, van Galen P, et al. Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer[ J ]. Science, 2013, 339 (6119) : 543-548.
  • 10Shackleton M, Quintana E, Fearon ER, et al. Heterogeneity in cancer: cancer stem cells versus clonal evolution[ J]. Cell, 2009, 138(5) : 822-829.

引证文献4

二级引证文献19

中华乳腺病杂志（电子版）
2014年 第6期

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