超早孕妇女血中早孕因子/chaperone10预示胚胎的存活
被引量：1
摘要
早孕因子（EPF ）／chaperone10是妊娠早期分泌的具有免疫抑制作用和生长因子作用的蛋白质，在授精12～48 h后就可利用玫瑰花结抑制实验（RIA）在妊娠血清中检测到。EPF最早是由Mor‐t o n等［1］在1974年描述，产生于授精后植入前，存在于妊娠早期。已经从人、猪、牛［2］、羊、红鹿等［3］哺乳动物妊娠血清和妊娠妇女子宫颈黏液中检测出了EPF活性。我们报道了可以从滋养细胞肿瘤患者体内测出EPF 活性。
出处
《山西医药杂志》
CAS
2014年第24期2954-2956,共3页
Shanxi Medical Journal
基金
山西高校科技研究开发自筹项目(20041321)
山西省回国留学基金(200375)
太原市科学技术基金(0503014)
参考文献8
-
1Morton H, Hogh V, C|unie GJA . Immunosuppression detec- ted in pregnant mice by rosette inhibition test[-J]. Nature, 1974,249:459-450.
-
2Ghaffari Laleh V, Ghaffari Laleh R, Pirany N, et al. Meas- urement o{ EPF for detection o{ cow pregnancy using rosette inhibition test[J]. Theriogenology, 2008,70 ( 1 ) : 105-107.
-
3Grosso M, Bellingeri R, Motta C, et al. Immunohistochemical distribution of early pregnancy factor in ovary, oviduct and placenta of pregnant gilts[J]. Biotech Histochem, 2014,3 : 1- 11.
-
4Morton H, Rolfe B, Clunie GJ. An early pregnancy factor de- tected in human serum by the rosette inhibition test[J]. Lan- cet, 1977,1 (8008) : 394-397.
-
5Morton H. Early pregnancy factor (EPF) : a link between fer- tilization and immunomodulation[J3. Aust J Biol Sci, 1984,37 (5-6) :393 407.
-
6Athanasas-Platsis S, Somodevilla-Torres MJ, Morton H, et al. Investigation of the immunocompetent cells that bind early pregnancy factor and preliminary studies of the early pregnan- cy actor target molecule[J], lmmunol Cell Biol, 2004,82 (4) : 361-369.
-
7Desai NN, Goldberg JM, Austin C, et al. The new rapid i carrier is an effective system for human embryo vitrification at both the blastocyst and cleavage stage[J]. Reprod BioI Endo- crinol,2013,15 : i 1-41.
-
8Refaat B. Role of activins in embryo implantation and diagnosis of ectopic pregnancy: a review[J]. Reprod Biol Endocrinol, 2005,12(1) :116.
同被引文献15
-
1Morton H, Hegh V, Clunie GJA. Immunosuppression detected in pregnant mice by rosette inhibition test[ J]. Nature, 1974,29:459-460.
-
2Fan XG, Zheng ZQ. A study of early pregnancy factor activity in preimplantation [ J]. Am J Reprod Immunol, 1997,37 ( 5 ) : 359- 364.
-
3Athanasas-Platsis S, Corcoran CM, Kaye PL, et al. Early pregnancy factor is required at two important stages of embryonic development in the mouse[J2. Am J Reprod lmmunol. 2000,43(4) :223-233.
-
4Cheng SJ, Zheng ZQ. Early pregnancy factor in cervical mucus of pregnant women. [ J ] Am J Reprod Immunol,2004 ,51 (2):102- 105.
-
5Bose R1, Cheng H, Sabbadini E, et al . Purified human early preg- nancy factor from preimplantation embryo possesses immunosuppre- sive properties [ J ]. Am J Obstet Gynecol. 1989,160 (4) :954-960.
-
6Kawamura K1 ,Fukuda J,Itoh H,et al. Chaperonin 10 in the rat o- ocytes and early embryos : its expression and activity for early preg- nancy factor[ J]. Am J Reprod Immunol,2000,44(4) :242-248.
-
7Martin CC1 ,Tang P, Barnardo G, et al . Expression of the chapero- nin 10 gene during zebrafish development. Cell Stress Chaperones. 2001 Jan;6( 1 ) :38-43.
-
8Grosso MC, Bellingeri RV, Motta CE, et al distribution of early pregnancy factor in ovary, oviduct and placenta of pregnant gilts[ J]. Biotech Histochem,2015 ,90( 1 ) :14-24.
-
9Fan X,Yan L,Jia S,et al . A study of early pregnancy factor ac- tivity in the sera of women with trophoblastic tumor. Am J Reprod ImmunoL 1999 Mar ;41 ( 3 ) :204-208.
-
10Ohnuma K, Ito K, Takahashi J, et al . Partial purification of mare early pregnancy factor [ J ]. Am J Reprod Immunol, 2004 , 51 (2) :95-101.
引证文献1
-
1阎冰,郝润喜,徐爱萍,闫彩萍,阎来喜,董张兰,房晓芬,孟霞,王建宇,樊晓光.胚胎围植入期超早孕妇女血中早孕因子的分离纯化[J].国际免疫学杂志,2015,38(5):413-418.
-
1樊晓光,乔常昕,马爱英,郭跃贞,李莉.人工授精者血中EPF活性的研究[J].山西医学院学报,1994,25(3):220-223.
-
2阎冰,郝润喜,徐爱萍,闫彩萍,阎来喜,董张兰,房晓芬,孟霞,王建宇,樊晓光.胚胎围植入期超早孕妇女血中早孕因子的分离纯化[J].国际免疫学杂志,2015,38(5):413-418.
-
3陈飞虎,苏宝田,徐光尧.EPF单克隆抗体杂交瘤细胞株的建立[J].免疫学杂志,1994,10(4):255-257. 被引量：3
-
4温志锋,练玉银,王家骥,聂湘辉,林燕棉.早孕因子分离纯化方法的优化[J].免疫学杂志,2012,28(12):1073-1076. 被引量：2
-
5张丽凤,苏宝田,史敏言.孕血清中早孕因子(EPF)的活性及其对T淋巴细胞亚群影响的研究[J].免疫学杂志,1989,5(2):21-25. 被引量：2
-
6王敏华,苏宝田.甲孕因子及肿瘤源性早孕因子对白细胞介素2...[J].中国实验临床免疫学杂志,1992,4(5):34-38. 被引量：4
-
7陈飞虎,余前,苏宝田,徐光尧,苏诚钦,吴亦伦,何丽娜.孕血清中早孕因子单克隆抗体的制备[J].安徽医科大学学报,1993,28(1):9-12. 被引量：5
-
8邓松华,苏宝田,徐振山.早孕因子对淋巴细胞增殖的影响[J].中国病理生理杂志,1998,14(4):410-413. 被引量：8
-
9左祥生,苏宝田,陈飞虎.微量抗原免疫法制备孕血清中早孕因子抗体及其鉴定[J].安徽医科大学学报,1993,28(2):109-111. 被引量：1
-
10张冬云,王晓华,刘桦.聚丙烯酰胺凝胶等电聚焦电泳法测定早孕因子的等电点[J].中国卫生检验杂志,2001,11(5):542-543. 被引量：4
