2011~2014年174例双胎妊娠产前诊断结果分析

Analysis of prenatal diagnosis results of 174 twin pregnancies between 2011 and 2014

目的通过分析近年来本科室双胎妊娠产前诊断结果,以探讨双胎产前诊断的安全性及意义。方法回顾性分析2011年1月1日至2014年2月28日于广东省妇幼保健院医学遗传中心行介入性产前诊断的174例双胎妊娠孕妇资料,分析其产前诊断指征、结果及结局。结果 1总共对283个胎儿取样,共检出29个异常,异常检出率10.2%(29/283)。其中胎儿预后不良异常15个,异常率5.3%(15/283)。2绒穿组/羊穿组/脐穿组术后2周内流产率分别为0.0%(0/7)、1.3%(2/149)、0.0%(0/18);双胎总流产率分别为14.3%(1/7)、3.4%(5/149)、0.0%(0/18)。结论介入性产前诊断技术能有效发现胎儿异常,对于符合产前诊断指征双胎孕妇,告知相关手术风险后仍需建议孕妇行相关介入性产前诊断检查。

Objective To investigate the safety of invasive prenatal diagnostic procedures of prenatal diagnosis for twins and its significance. Method This study retrospectively analyzed the 174 twin preg- nancies who took invasive prenatal diagnostic procedures guided by ultrasound in Guangdong Women and children＇s hospital from 2011-01-01 to 2014-02-08. The indications, results and outcomes of invasive pre- natal diagnostic procedures were analyzed. Results ①Totally 283 fetus were examined, and there were 29 abnormal results. The abnormal detection rate was 10.2% （29/283）. There were 15 severely abnormal results. The rate was 5.3% （15/283）. ②The fetal loss rate within two weeks after the procedure were 0.0%（0/7）, 1. 3% （2/149）,0. 0% （0/18）respectively in the different group of chorionic villi sampling group/mniocentesis group / cordocentesis group. The total fetal loss rate were 14.3% （1/7）,3.4% （5/ 149）,0.0%（0/18）respectively. Conclusions Invasive prenatal diagnostic procedures can find fetus with congenital abnormality effectively. Doctors should advice twin pregnancies who had indications to take in- vasive prenatal diagnostic procedure after warning relative risks.